The term “epigenetics” has been widely used and abused (Greally, 2018) but the most
compelling definition of epigenetics is the study of changes in gene function that are …

The human and mouse genomes contain instructions that specify RNAs and proteins and
govern the timing, magnitude, and cellular context of their production. To better delineate …

The human and mouse genomes contain instructions that specify RNAs and proteins and
govern the timing, magnitude, and cellular context of their production. To better delineate …

Different cell types within a single organism are generally distinguished by strikingly different
patterns of gene expression, which are dynamic throughout development and adult life …

Single-cell multi-omics has recently emerged as a powerful technology by which different
layers of genomic output—and hence cell identity and function—can be recorded …

One of the major challenges in genetics today is to understand the causes of complex
genetic diseases. The genes involved in these disorders are thought to interact with poorly …

Histone modifications play a key role in regulating transcription and thus ultimately regulate
cellular development and differentiation. To understand how histone modifications influence …

Despite the explosive growth of genomic data, functional annotation of regulatory
sequences remains difficult. Here, we introduce" comparative epigenomics"—interspecies …

Current catalogs of regulatory sequences in the human genome are still incomplete and lack
cell type resolution. To profile the activity of gene regulatory elements in diverse cell types …

Cancer evolution at all stages is driven by both epigenetic abnormalities as well as genetic
alterations. Dysregulation of epigenetic control events may lead to abnormal patterns of …