Gene expression requires successful communication between enhancer and promoter
regions, whose activities are regulated by a variety of factors and associated with distinct …

Comparative genome analyses reveal that organismal complexity scales not with gene
number but with gene regulation. Recent efforts indicate that the human genome likely …

Embryonic (ES) and epiblast (EpiSC) stem cells are pluripotent but committed to an
embryonic lineage fate. Conversely, trophoblast (TS) and extraembryonic endoderm (XEN) …

Last October, scientists gathered in Amsterdam to celebrate the start of BLUEPRINT
(http://www. blueprint-epigenome. eu/), an EU-funded consortium that will generate …

Much of the recent advances in functional genomics owe to developments in next-
generation sequencing technology, which has contributed to the exponential increase of …

Epigenomes are comprised, in part, of all genome-wide chromatin modifications, including
DNA methylation and histone modifications. Unlike the genome, epigenomes are dynamic …

One of the most exciting frontiers in both epigenetics and genome sciences is the new field
of epigenomics. This new discipline promises novel insights into the genome because of its …

Sequencing of genomes, including that of humans, has revolutionized our understanding of
genome organization and accelerated the hunt for disease-causing mutations. New studies …