An update on the cardiac effects of erythropoietin cardioprotection by erythropoietin and the lessons learnt from studies in neuroprotection

MA Bogoyevitch - Cardiovascular research, 2004 - academic.oup.com
Erythropoietin (Epo) was once thought to act exclusively in the formation of red blood cells.
As recently reviewed by Smith et al.[Cardiovasc. Res. 59 (2003) 538–548], Epo can also act …

Molecular basis of cardioprotection by erythropoietin

D Burger, A Xenocostas… - Current molecular …, 2009 - ingentaconnect.com
Erythropoietin (EPO), a glycoprotein essential for red blood cell production acts on several
non-erythropoietic tissues. The EPO receptor (EPOR) is expressed in a variety of cell types …

Erythropoietin and the heart: physiological effects and the therapeutic perspective

F Sanchis-Gomar, JL Garcia-Gimenez… - International journal of …, 2014 - Elsevier
Erythropoietin (Epo) has been thought to act exclusively on erythroid progenitor cells. The
identification of Epo receptor (EpoR) in non-haematopoietic cells and tissues including …

Do non-hemopoietic effects of erythropoietin play a beneficial role in heart failure?

R Latini, M Brines, F Fiordaliso - Heart failure reviews, 2008 - Springer
Erythropoietin (EPO) is not solely a hormone charged with regulating the proliferation and
differentiation of erythroid cells. Indeed, EPO is synthesized locally by many cells, especially …

Protective effects of erythropoietin in cardiac ischemia: from bench to bedside

E Lipšic, RG Schoemaker, P van der Meer… - Journal of the American …, 2006 - jacc.org
Erythropoietin (EPO) is a hypoxia-induced hormone produced in the kidneys that stimulates
hematopoiesis in the bone marrow. However, recent studies have also shown important …

A novel protective effect of erythropoietin in the infarcted heart

CJ Parsa, A Matsumoto, J Kim, RU Riel… - The Journal of …, 2003 - Am Soc Clin Investig
Erythropoietin (EPO) has been shown to protect neurons from ischemic stroke, but can also
increase thrombotic events and mortality rates in patients with ischemic heart disease. We …

Timing of erythropoietin treatment for cardioprotection in ischemia/reperfusion

E Lipšic, P van der Meer, RH Henning… - Journal of …, 2004 - journals.lww.com
Erythropoietin (EPO) is a hormone known to stimulate hematopoiesis. However, recent
research suggests additional properties of EPO, such as protection against …

Erythropoietin improves left ventricular function and coronary flow in an experimental model of ischemia‐reperfusion injury

P van der Meer, E Lipsic, RH Henning… - European Journal of …, 2004 - Wiley Online Library
Background: Recent studies show that erythropoietin (EPO) plays a protective role in brain
ischemia. In this condition, administration of EPO protects neurons from ischemic damage …

Cardiovascular effects of erythropoietin: an update

AVR Santhanam, LV d'Uscio, ZS Katusic - Advances in pharmacology, 2010 - Elsevier
Erythropoietin (EPO) is a therapeutic product of recombinant DNA technology and it has
been in clinical use as stimulator of erythropoiesis over the last two decades. Identification of …

Erythropoietin and treatment of non-anemic conditions—cardiovascular protection

D Fliser, H Haller - Seminars in hematology, 2007 - Elsevier
The well-established physiological function of erythropoietin (EPO) is the induction of
erythropoiesis. A growing body of evidence indicates that EPO has tissue-protective effects …