Exploring the imbalance of periodontitis immune system from the cellular to molecular level

L He, L Liu, T Li, D Zhuang, J Dai, B Wang, L Bi - Frontiers in Genetics, 2021 - frontiersin.org
Periodontitis is a common chronic inflammatory disease of periodontal tissue, mostly
concentrated in people over 30 years old. Statistics show that compared with foreign …

Deep learning reveals key immunosuppression genes and distinct immunotypes in periodontitis

W Ning, A Acharya, Z Sun, AC Ogbuehi, C Li… - Frontiers in …, 2021 - frontiersin.org
Background Periodontitis is a chronic immuno-inflammatory disease characterized by
inflammatory destruction of tooth-supporting tissues. Its pathogenesis involves a …

Bioinformatics analysis and reveal potential crosstalk genetic and immune relationships between atherosclerosis and periodontitis

W Dong, Y Gong, B Yang, B Li - Scientific Reports, 2023 - nature.com
Periodontitis is an inflammatory and immune-related disease with links to several systemic
diseases, and the pathological process of atherosclerosis also involves inflammatory and …

Immune infiltration and diagnostic value of immune‐related genes in periodontitis using bioinformatics analysis

D Lai, W Ma, J Wang, L Zhang, J Shi… - Journal of Periodontal …, 2023 - Wiley Online Library
Abstract Background and Objectives Periodontitis, which is a chronic inflammatory
periodontal disease resulting in destroyed periodontal tissue, is the leading cause of tooth …

Screening of feature genes related to immune and inflammatory responses in periodontitis

A Duan, Y Zhang, G Yuan - BMC Oral Health, 2023 - Springer
Background Immune and inflammatory responses are important in the occurrence and
development of periodontitis. The aim of this study was to screen for immune-related genes …

Immune landscape of periodontitis unveils alterations of infiltrating immunocytes and molecular networks-aggregating into an interactive web-tool for periodontitis …

X Zhang, Q Wang, X Yan, Y Shan, L Xing, M Li… - Journal of Translational …, 2020 - Springer
Background Immunity reaction plays an essential role in periodontitis progress and we aim
to investigate the underlying regulatory network of immune reactions in periodontitis …

Construction of artificial neural network diagnostic model and analysis of immune infiltration for periodontitis

J Xiang, W Huang, Y He, Y Li, Y Wang, R Chen - Frontiers in Genetics, 2022 - frontiersin.org
Background: Periodontitis is a chronic inflammatory disease leading to tooth loss in severe
cases, and early diagnosis is essential for periodontitis prevention. This study aimed to …

Identification of Endoplasmic Reticulum Stress‐Related Biomarkers of Periodontitis Based on Machine Learning: A Bioinformatics Analysis

Q Zhang, Y Jiao, N Ma, L Zhang, Y Song - Disease Markers, 2022 - Wiley Online Library
Objective. To screen for potential endoplasmic reticulum stress‐(ERS‐) related biomarkers
of periodontitis using machine learning methods and explore their relationship with immune …

Potential diagnostic markers and therapeutic targets for periodontitis and Alzheimer's disease based on bioinformatics analysis

K Yang, Z Zhang, Q Zhang, H Zhang… - Journal of …, 2024 - Wiley Online Library
Abstract Background and Objective As a chronic inflammatory disease, periodontitis
threatens oral health and is a risk factor for Alzheimer's disease (AD). There is growing …

Identification of hub genes related to immune cell infiltration in periodontitis using integrated bioinformatic analysis

X Gao, C Jiang, S Yao, L Ma, X Wang… - Journal of Periodontal …, 2022 - Wiley Online Library
Background and objective Periodontitis is an inflammatory disease of the periodontium.
However, the hub genes in periodontitis and their correlation with immune cells are not …