The mechanisms underlying neuropathic pain caused by nerve injury are not well
understood. Inflammatory responses in injured nerves are likely to be key contributing …

J. Neurochem.(2011) 118, 841–854. Abstract Following various types of nerve injury,
cyclooxygenase 2 and prostaglandin E2 (PGE2) are universally and chronically up …

The release of inflammatory mediators from immune and glial cells either in the peripheral or
CNS may have an important role in the development of physiopathological processes such …

Inflammatory macrophages play a fundamental role in neuropathic pain. In this study, we
demonstrate the effects of peripheral interleukin-13 (IL-13) on neuropathic pain after partial …

There is increasing evidence that inflammatory (M1-polarized) macrophages drive the
nonresolving neuroinflammation that causes neuropathic pain after nerve injury. As …

Prostacyclin is an important mediator of peripheral pain sensation. Here, we investigated its
potential participation in mediating neuropathic pain and found that prostacyclin receptor …

Abstract Interleukin-17 (IL-17) is involved in a wide range of inflammatory disorders and in
recruitment of inflammatory cells to injury sites. A recent study of IL-17 knock-out mice …

We previously reported that cyclooxygenase 2 (COX2) is up-regulated in macrophages in
injured nerve of rats with partial sciatic nerve ligation (PSNL) and that local injection of the …

Cytokines, essential mediators of inflammatory and immune responses, play an important
role in the pathophysiological processes associated with neuropathic pain following …

Background Recent studies show that inflammatory processes may contribute to
neuropathic pain. Cyclooxygenase-2 (Cox-2) is an inducible enzyme responsible for …