Next-generation sequencing for research and diagnostics in kidney disease

KY Renkema, MF Stokman, RH Giles… - Nature Reviews …, 2014 - nature.com
The advent of next-generation sequencing technologies has enabled genetic nephrology
research to move beyond single gene analysis to the simultaneous investigation of …

Contribution of predictive and prognostic biomarkers to clinical research on chronic kidney disease

M Provenzano, S Rotundo, P Chiodini… - International Journal of …, 2020 - mdpi.com
Chronic kidney disease (CKD), defined as the presence of albuminuria and/or reduction in
estimated glomerular filtration rate (eGFR)< 60 mL/min/1.73 m2, is considered a growing …

The use of targeted biomarkers for chronic kidney disease

P Devarajan - Advances in chronic kidney disease, 2010 - Elsevier
There is a paucity of sensitive and specific biomarkers for the early prediction of CKD
progression. The recent application of innovative technologies such as functional genomics …

[HTML][HTML] Genetics in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) controversies conference

A Köttgen, E Cornec-Le Gall, J Halbritter, K Kiryluk… - Kidney international, 2022 - Elsevier
Numerous genes for monogenic kidney diseases with classical patterns of inheritance, as
well as genes for complex kidney diseases that manifest in combination with environmental …

The tissue proteome in the multi-omic landscape of kidney disease

MM Rinschen, J Saez-Rodriguez - Nature Reviews Nephrology, 2021 - nature.com
Kidney research is entering an era of 'big data'and molecular omics data can provide
comprehensive insights into the molecular footprints of cells. In contrast to transcriptomics …

Assessment of metabolomic and proteomic biomarkers in detection and prognosis of progression of renal function in chronic kidney disease

E Nkuipou-Kenfack, F Duranton, N Gayrard, A Argiles… - PloS one, 2014 - journals.plos.org
Chronic kidney disease (CKD) is part of a number of systemic and renal diseases and may
reach epidemic proportions over the next decade. Efforts have been made to improve …

Integrative biology identifies shared transcriptional networks in CKD

S Martini, V Nair, BJ Keller, F Eichinger… - Journal of the …, 2014 - journals.lww.com
A previous meta-analysis of genome-wide association data by the Cohorts for Heart and
Aging Research in Genomic Epidemiology and CKDGen consortia identified 16 loci …

The expanding phenotypic spectra of kidney diseases: insights from genetic studies

MF Stokman, KY Renkema, RH Giles… - Nature Reviews …, 2016 - nature.com
Next-generation sequencing (NGS) has led to the identification of previously unrecognized
phenotypes associated with classic kidney disease genes. In addition to improving …

[图书][B] Biomarkers of kidney disease

CL Edelstein - 2016 - books.google.com
Biomarkers of Kidney Disease, Second Edition, focuses on the basic and clinical research of
biomarkers in common kidney diseases, detailing the characteristics of an ideal biomarker …

The growing challenge of chronic kidney disease: an overview of current knowledge

R Borg, N Carlson, J Søndergaard… - International Journal of …, 2023 - Wiley Online Library
Chronic kidney disease (CKD) is becoming one of the world's most prevalent
noncommunicable chronic diseases. The World Health Organization projects CKD to …