Osteoblasts play a critical role in the maintenance of bone mass through bone formation and
regulation of bone resorption. Targeted expression of a constitutively active engineered Gi …

Age-related bone loss is an important risk factor for fractures in the elderly; it results from an
imbalance in bone remodeling mainly due to decreased bone formation. We have …

G protein-coupled receptor (GPCR) signaling in osteoblasts (OBs) is an important regulator
of bone formation. We previously described a mouse model expressing Rs1, an engineered …

ABSTRACT G‐protein‐coupled receptors (GPCRs) are key regulators of skeletal
homeostasis and are likely important in fracture healing. Because GPCRs can activate …

G-protein coupled receptors (GPCRs) and their ligands are critical for normal osteoblast
formation and function. GPCRs mediate a wide variety of biological processes and are …

Osteoblasts are essential for maintaining bone mass, avoiding osteoporosis, and repairing
injured bone. Activation of osteoblast G protein-coupled receptors (GPCRs), such as the …

G protein-coupled receptors (GPCRs) coupled to activation of Gs, such as the PTH1 receptor
(PTH1R), have long been known to regulate skeletal function and homeostasis. However …

STEOPOROSIS is characterized by low bone mass and the 0 development of fractures,
resulting from the loss of skeletal architecture. Whereas the underlying mechanisms for bone …

To investigate the role of G protein-coupled receptor kinases (GRKs) in regulating bone
formation in vivo, we overexpressed the potent G protein-coupled receptor (GPCR) regulator …

Age‐dependent changes in skeletal growth are important for regulating skeletal expansion
and determining peak bone mass. However, how G protein–coupled receptors (GPCRs) …