Redox homeostasis and cellular antioxidant systems: crucial players in cancer growth and therapy

B Marengo, M Nitti, AL Furfaro, R Colla… - Oxidative medicine …, 2016 - Wiley Online Library
Reactive oxygen species (ROS) and their products are components of cell signaling
pathways and play important roles in cellular physiology and pathophysiology. Under …

The tumorigenic roles of the cellular REDOX regulatory systems

SA Castaldo, JR Freitas, NV Conchinha… - Oxidative medicine …, 2016 - Wiley Online Library
The cellular REDOX regulatory systems play a central role in maintaining REDOX
homeostasis that is crucial for cell integrity, survival, and proliferation. To date, a substantial …

Oxidative stress in cancer cell metabolism

S Arfin, NK Jha, SK Jha, KK Kesari, J Ruokolainen… - Antioxidants, 2021 - mdpi.com
Reactive oxygen species (ROS) are important in regulating normal cellular processes
whereas deregulated ROS leads to the development of a diseased state in humans …

The relationship of redox with hallmarks of cancer: the importance of homeostasis and context

F Xing, Q Hu, Y Qin, J Xu, B Zhang, X Yu… - Frontiers in …, 2022 - frontiersin.org
Redox homeostasis is a lifelong pursuit of cancer cells. Depending on the context, reactive
oxygen species (ROS) exert paradoxical effects on cancers; an appropriate concentration …

ROS generation and antioxidant defense systems in normal and malignant cells

AV Snezhkina, AV Kudryavtseva… - Oxidative medicine …, 2019 - Wiley Online Library
Reactive oxygen species (ROS) are by‐products of normal cell activity. They are produced
in many cellular compartments and play a major role in signaling pathways. Overproduction …

Targeting antioxidants for cancer therapy

A Glasauer, NS Chandel - Biochemical pharmacology, 2014 - Elsevier
Cancer cells are characterized by an increase in the rate of reactive oxygen species (ROS)
production and an altered redox environment compared to normal cells. Furthermore, redox …

ROS signalling in the biology of cancer

JN Moloney, TG Cotter - Seminars in cell & developmental biology, 2018 - Elsevier
Increased reactive oxygen species (ROS) production has been detected in various cancers
and has been shown to have several roles, for example, they can activate pro-tumourigenic …

Cellular redox pathways as a therapeutic target in the treatment of cancer

AJ Montero, J Jassem - Drugs, 2011 - Springer
The vulnerability of some cancer cells to oxidative signals is a therapeutic target for the
rational design of new anticancer agents. In addition to their well characterized effects on …

Reactive oxygen species in cancer biology and anticancer therapy

Y Yang, S Karakhanova, J Werner… - Current medicinal …, 2013 - ingentaconnect.com
Reactive oxygen species (ROS) are a group of highly reactive chemicals under tight control
of intracellular antioxidants. The balance in oxidation-antioxidation is essential for …

Redox-mediated mechanism of chemoresistance in cancer cells

EK Kim, MG Jang, MJ Song, D Kim, Y Kim, HH Jang - Antioxidants, 2019 - mdpi.com
Cellular reactive oxygen species (ROS) status is stabilized by a balance of ROS generation
and elimination called redox homeostasis. ROS is increased by activation of endoplasmic …