Extracellular‐regulated kinases and phosphatidylinositol 3‐kinase are involved in brain‐derived neurotrophic factor‐mediated survival and neuritogenesis of the …

M Encinas, M Iglesias, N Llecha… - Journal of …, 1999 - Wiley Online Library
Retinoic acid (RA) induces the differentiation of many cell lines, including those derived from
neuroblastoma. RA treatment of SH‐SY5Y cells induces the appearance of functional Trk B …

Induction of TrkB by retinoic acid mediates biologic responsiveness to BDNF and differentiation of human neuroblastoma cells

DR Kaplan, K Matsumoto, E Lucarelli, CJ Thielet - Neuron, 1993 - cell.com
Retinoic acid (RA) induces the neuronal differentiation of many human neuroblastoma cell
lines. In this study, we show that RA treatment of neuroblastoma cells induces the …

Signal transduction pathways through TRK‐A and TRK‐B receptors in human neuroblastoma cells

T Sugimoto, H Kuroda, Y Horii… - Japanese journal of …, 2001 - Wiley Online Library
Little is known about the signal transduction pathways of TRK family receptors in
neuroblastoma (NB) cells. In this study, an NB cell line, designated MP‐N‐TS, was …

Differences in survival‐promoting effects and intracellular signaling properties of BDNF and IGF‐1 in cultured cerebral cortical neurons

M Yamada, K Tanabe, K Wada… - Journal of …, 2001 - Wiley Online Library
Brain‐derived neurotrophic factor (BDNF) and insulin‐like growth factor‐1 (IGF‐1) act on
various neurons of the CNS as neurotrophic factors promoting neuronal differentiation and …

Brain‐derived neurotrophic factor induces excitotoxic sensitivity in cultured embryonic rat spinal motor neurons through activation of the phosphatidylinositol 3‐kinase …

HJL Fryer, DH Wolf, RJ Knox… - Journal of …, 2000 - Wiley Online Library
Neurotrophic factors (NTFs) can protect against or sensitize neurons to excitotoxicity. We
studied the role played by various NTFs in the excitotoxic death of purified embryonic rat …

Insulin receptor substrate (IRS)-1 and IRS-2 are tyrosine-phosphorylated and associated with phosphatidylinositol 3-kinase in response to brain-derived neurotrophic …

M Yamada, H Ohnishi, S Sano, A Nakatani… - Journal of Biological …, 1997 - ASBMB
Brain-derived neurotrophic factor (BDNF), a member of the neurotrophins, promotes
differentiation and survival of various types of neurons in the central nervous system. BDNF …

Molecular dissection of TrkA signal transduction pathways mediating differentiation in human neuroblastoma cells

A Eggert, N Ikegaki, X Liu, TT Chou, VM Lee… - Oncogene, 2000 - nature.com
Activation of the neurotrophin receptor TrkA by its ligand nerve growth factor (NGF) initiates
a cascade of signaling events leading to neuronal differentiation in vitro and might play an …

NT‐3‐mediated TrkC receptor activation promotes proliferation and cell survival of rodent progenitor oligodendrocyte cells in vitro and in vivo

S Kumar, MA Kahn, L Dinh… - Journal of neuroscience …, 1998 - Wiley Online Library
We have previously described the expression of a functional full‐length trkC transcript for
neurotrophin‐3 (NT‐3) receptor in oligodendroglia (OL) cells (Kumar and de Vellis, 1996) …

Signaling pathways and survival effects of BDNF and NT-3 on cultured cerebellar granule cells

T Nonomura, T Kubo, T Oka, K Shimoke… - Developmental brain …, 1996 - Elsevier
We investigated the signaling pathways exerted by brain-derived neurotrophic factor (BDNF)
and neurotrophin-3 (NT-3) in relation to their survival-promoting effects on dissociated …

Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase

M Hetman, K Kanning, JE Cavanaugh, Z Xia - Journal of Biological …, 1999 - ASBMB
Apoptosis is a form of programmed cell death that plays a pivotal role during development
and in the homeostasis of the adult nervous systems. However, mechanisms that regulate …