The serotonin transporter gene-linked polymorphic region (5-HTTLPR) and cortisol stress reactivity: a meta-analysis

R Miller, M Wankerl, T Stalder, C Kirschbaum… - Molecular …, 2013 - nature.com
Recent meta-analyses have stimulated an active debate on whether the serotonin
transporter gene-linked polymorphic region (5-HTTLPR) is associated with an elevated …

DNA methylation profiles within the serotonin transporter gene moderate the association of 5-HTTLPR and cortisol stress reactivity

N Alexander, M Wankerl, J Hennig, R Miller… - Translational …, 2014 - nature.com
The serotonin transporter gene-linked polymorphic region (5-HTTLPR) has been implicated
in moderating vulnerability to stress-related psychopathology upon exposure to …

Interaction of serotonin transporter gene-linked polymorphic region and stressful life events predicts cortisol stress response

A Mueller, D Armbruster, DA Moser, T Canli… - …, 2011 - nature.com
There has been significant controversy whether stressful life events (SLEs) experienced
over the lifespan may elevate the risk of depression in individuals who are homozygous for …

Interaction of the serotonin transporter-linked polymorphic region and environmental adversity: increased amygdala-hypothalamus connectivity as a potential …

N Alexander, T Klucken, G Koppe, R Osinsky… - Biological …, 2012 - Elsevier
BACKGROUND: Gene by environment (G× E) interaction between genetic variation in the
promoter region of the serotonin transporter gene (serotonin transporter-linked polymorphic …

Healthy young women with serotonin transporter SS polymorphism show a pro-inflammatory bias under resting and stress conditions

CA Fredericks, EM Drabant, MD Edge, JM Tillie… - Brain, Behavior, and …, 2010 - Elsevier
The study of functionally relevant biological effects of serotonin transporter gene promoter
region (5-HTTLPR) polymorphisms is especially important given the current controversy …

Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression

RC Culverhouse, NL Saccone, AC Horton, Y Ma… - Molecular …, 2018 - nature.com
The hypothesis that the S allele of the 5-HTTLPR serotonin transporter promoter region is
associated with increased risk of depression, but only in individuals exposed to stressful …

Gene–environment interactions predict cortisol responses after acute stress: implications for the etiology of depression

N Alexander, Y Kuepper, A Schmitz, R Osinsky… - …, 2009 - Elsevier
BACKGROUND: Growing evidence suggests that the serotonin transporter polymorphism (5-
HTTLPR) interacts with adverse environmental influences to produce an increased risk for …

Current developments and controversies: does the serotonin transporter gene-linked polymorphic region (5-HTTLPR) modulate the association between stress and …

M Wankerl, S Wüst, C Otte - Current Opinion in Psychiatry, 2010 - journals.lww.com
Whereas there is no doubt that the meta-analyses are methodologically sound, it appears
that this technique is only in part suitable for appraising all of the available evidence …

Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis

N Risch, R Herrell, T Lehner, KY Liang, L Eaves, J Hoh… - Jama, 2009 - jamanetwork.com
Context Substantial resources are being devoted to identify candidate genes for complex
mental and behavioral disorders through inclusion of environmental exposures following the …

The serotonin transporter polymorphism (5‐HTTLPR): allelic variation and links with depressive symptoms

N Goldman, DA Glei, YH Lin… - Depression and …, 2010 - Wiley Online Library
Background: We compare the genotype distribution for the serotonin transporter
polymorphism (5‐HTTLPR) in a sample of older Taiwanese adults with samples of various …