Cascade Radical 1,6-Addition/Cyclization of para-Quinone Methides: Leading to Spiro[4.5]deca-6,9-dien-8-ones

R Pan, L Hu, C Han, A Lin, H Yao - Organic letters, 2018 - ACS Publications
A cascade three-component iodoazidation of para-quinone methides to construct spiro [4.5]
deca-6, 9-dien-8-ones under mild conditions has been developed. The chemoselective 1, 6 …

Radical Deaminative ipso-Cyclization of 4-Methoxyanilines with 1,7-Enynes for Accessing Spirocyclohexadienone-Containing Cyclopenta[c]quinolin-4-ones

J Li, WW Zhang, XJ Wei, F Liu, WJ Hao… - The Journal of …, 2017 - ACS Publications
A new C-center radical-triggered bicyclization cascade of N-tethered 1, 7-enynes for forming
28 examples of biologically interesting spirocyclohexadienone-containing cyclopenta [c] …

Addition of sulfonylphthalides to para-quinone methides: Selective 1, 6-additions and oxidative annulations

KK Gond, MR Maddani - Organic & Biomolecular Chemistry, 2023 - pubs.rsc.org
KOtBu mediated addition of sulfonylphthalides to p-quinone methides led to the selective
synthesis of isochroman-1, 4-diones and addition products. Interestingly, isochroman-1, 4 …

Synthesis of spiro [2.5] octa-4, 7-dien-6-one with consecutive quaternary centers via 1, 6-conjugate addition induced dearomatization of para-quinone methides

K Gai, X Fang, X Li, J Xu, X Wu, A Lin… - Chemical …, 2015 - pubs.rsc.org
An efficient one-pot approach for the synthesis of spiro [2.5] octa-4, 7-dien-6-ones by
employing para-quinone methides has been developed. The reaction proceeded smoothly …

Copper-catalyzed radical cascades of para-quinone methides with AIBN and H 2 O via α-cyanoalkylation by C–C bond cleavage: new access to benzofuran-2 (3 H) …

J Yu, HX Sheng, SW Wang, ZH Xu, S Tang… - Chemical …, 2019 - pubs.rsc.org
We describe the first one-pot construction of a benzofuran-2 (3H)-one scaffold via a radical
cascade reaction of para-quinone methides with azodiisobutyronitrile and water. In the …

Cu-Catalyzed radical-triggered spirotricyclization of enediynes and enyne-nitriles for the synthesis of pentacyclic spiroindenes

HD Zuo, XS Ji, C Guo, SJ Tu, WJ Hao… - Organic Chemistry …, 2021 - pubs.rsc.org
A new copper-catalyzed radical-triggered fluoromethylation-spirotricyclization of enediyne-
and enyne-nitrile-containing para-quinone methides (p-QMs) was reported for the first time …

1, 6-Addition of vinyl p-quinone methides with cyclic sulfamidate imines: access to 4-hydroxyaryl-2, 6-diarylpyridines

S Guin, SK Gudimella, S Samanta - Organic & Biomolecular Chemistry, 2020 - pubs.rsc.org
A simple and powerful one-pot regioselective 1, 6-addition elimination–6π-aza-
electrocyclization–aromatization reaction of vinyl/dienyl-substituted para-quinone methides …

Synthesis of spirocyclohexadienones through radical cascade reactions featuring 3-fold carbon–carbon bond formation

N Hegmann, L Prusko, MR Heinrich - Organic letters, 2017 - ACS Publications
The radical 5-exo cyclization starting from 2-allyloxyphenyldiazonium ions can be employed
for the diastereoselective synthesis of ortho-spirocyclohexadienones through a consecutive …

[3 + 2] Cycloaddition of para-Quinone Methides with Nitrile Imines: Approach to Spiro-pyrazoline-cyclohexadienones

Y Su, Y Zhao, B Chang, X Zhao, R Zhang… - The Journal of …, 2019 - ACS Publications
[3+ 2] cycloaddition of para-quinone methides with nitrile imines under mild conditions has
been achieved. The corresponding spiro-pyrazoline-cyclohexadienone products were …

Base-mediated tandem 1, 6-addition/cyclization/isomerization reactions between para-quinone methides and benzyl chlorides: approaches to diverse frameworks at …

S Zhao, Y Zhu, M Zhang, X Song, J Chang - Synthesis, 2019 - thieme-connect.com
Base-mediated stereospecific tandem reactions using para-quinone methides and carbene-
like benzyl chlorides are developed. DBU-mediated 1, 6-addition/cyclization/isomerization …