Mycobacterium tuberculosis (Mtb) infection reveals complex and dynamic host-pathogen
interactions, leading to host protection or pathogenesis. Using a unique transcriptome …

Although mouse infection models have been extensively used to study the host response to
Mycobacterium tuberculosis, their validity in revealing determinants of human tuberculosis …

Mycobacterium tuberculosis is an obligate human pathogen capable of persisting in
individual hosts for decades. We sequenced the genomes of 21 strains representative of the …

The genus Mycobacterium includes a variety of species with differing phenotypic properties,
including growth rate, pathogenicity and environment-and host-specificity. Although many …

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains a
leading cause of death due to infection in humans. To more effectively combat this …

Epigenetic mechanisms are pivotal in regulating gene expression during cellular response
to extracellular stimuli. Bacterial infections have a profound effect on the host epigenome …

Intracellular pathogens such as Mycobacterium tuberculosis have evolved strategies for
coping with the pressures encountered inside host cells. The ability to coordinate global …

The PhoP–PhoR two-component system is essential for virulence and intracellular growth of
Mycobacterium tuberculosis (MTB) in human and mouse macrophages or in mice. Here …

First achieved in 1998 by Cole et al., the complete genome sequence of Mycobacterium
tuberculosis continues to provide an invaluable resource to understand tuberculosis (TB) …

Mycobacterium tuberculosis (Mtb) and HIV are known to mutually support each other during
co-infection by multiple mechanisms. This synergistic influence could be either by direct …