In the global fight against the COVID-19 pandemic caused by the highly transmissible SARS-
CoV-2 virus, the search for potent medications is paramount. With a focused investigation on …

The new coronavirus SARS-CoV-2 is the cause of the COVID-19 pandemic, which has
created an incomparable global health problem. PLpro is a key protein involved in viral …

The COVID-19 pandemic, instigated by the emergence of the novel coronavirus, SARS-CoV-
2, created an incomparable global health crisis. Due to its highly virulent nature, identifying …

Papain-like protease (PLpro) is a viral protease found in some coronaviruses, including
SARS-CoV-2, the virus that causes COVID-19. Inhibition of PLpro activity could potentially …

Papain-like protease (PLpro) is a promising therapeutic target against SARS-CoV-2, but its
restricted S1/S2 subsites pose an obstacle in developing active site-directed inhibitors. We …

The pandemic caused by SARS-CoV-2 (SCoV-2) has impacted the world in many ways and
the virus continues to evolve and produce novel variants with the ability to cause frequent …

Coronaviruses such as SARS-CoV-2 encode a conserved papain-like protease (PLpro) that
is crucial for viral replication and immune evasion, making it a prime target for antiviral drug …

Coronavirus disease 2019 (COVID-19) is an ongoing global pandemic caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with very limited treatments so far …

Abstract SARS-CoV-2's papain-like protease (PLpro) interaction with ligands has recently
been explored with a myriad of crystal structures. We used molecular dynamics (MD) …

Viral papain-like cysteine protease (PLpro, NSP3) is essential for SARS-CoV-2 replication
and represents a promising target for the development of antiviral drugs. Here, we used a …