Diabetes mellitus, a disorder of metabolism, results in the elevation of glucose level in the
blood. In this hyperglycaemic condition, aldose reductase overexpresses and leads to …

Aldose reductase [ALR2; EC 1.1. 1.21], a key enzyme of polyol pathway, catalyzes NADPH-
dependent reduction of glucose to sorbitol (Sorbitol pathway), and an excessive …

The development of long-term diabetic complications in diabetes patients is considered to
be closely related to hyperglycaemia. Aldose reductase was first found to be implicated in …

Most long-term diabetic patients develop microvascular diseases such as retinopathy,
nephropathy and neuropathy. Although tight control of blood glucose greatly reduces the …

Diabetes mellitus occurrence has been associated to the modification of the physiological
levels of glucose and is often accompanied by several long-term complications, namely …

Aldose reductase (AR) is an NADPH-dependent enzyme that catalyses the reduction of the
aldehyde to the corresponding alcohols. Diabetic complications including neuropathy …

Despite recent advances both in the chemistry and molecular pharmacology of antidiabetic
drugs, diabetes still remains a life‐threatening disease, which tends to spread all over the …

The 'late complications' of diabetes mellitus, ie, nephropathy, neuropathy and retinopathy
are firmly rooted in inadequate control of blood glucose: hyperglycaemia. Hyperglycaemia …

Diabetic complications are attributed to hyperglycaemic condition which is in turn associated
with the polyol pathway and advanced glycation end products. Aldose reductase (AR) is the …

Diabetes mellitus is a chronic metabolic disease characterized by abnormal glucose
metabolism. Aldose reductase (AR) is the first enzyme in the polyol pathway and converts …