Pregnancy can exacerbate or prompt the onset of stress-related disorders, such as post-
traumatic stress disorder (PTSD). PTSD is associated with heightened stress responsivity …

Prenatal maternal stress has a negative impact on child health but the mechanisms through
which maternal stress affects child health are unclear. Epigenetic variation, such as DNA …

Importance Adverse childhood experiences (ACEs), potentially traumatic experiences
occurring before the age of 18 years, are associated with epigenetic aging later in life and …

Objective Maternal antenatal depression may compromise the fetal developmental milieu
and contribute to individual differences in aging and disease trajectories in later life. We …

Previous studies suggest epigenetic alterations may contribute to the association between
maternal prenatal depression and adverse offspring outcomes. Developmental researchers …

Emerging research suggests associations of physical and psychosocial stressors with
epigenetic aging. Although this work has included early-life exposures, data on maternal …

Accelerated epigenetic aging relative to chronological age has been found to be associated
with higher risk of mortality in adults. However, little is known about whether and how in …

BACKGROUND Antenatal maternal depression is associated with poor pregnancy
outcomes and long-term effects on the offspring. Previous studies have identified links …

Background Physiological maternal stress response, such as imbalance in the
glucocorticoid pathway and immune system seems to be mediated by DNA methylation …

Stress during pregnancy may impact subsequent generations, which is demonstrated by an
increased susceptibility to childhood and adulthood health problems in the children and …