CRISPR-Cas systems: prokaryotes upgrade to adaptive immunity
R Barrangou, LA Marraffini - Molecular cell, 2014 - cell.com
Clustered regularly interspaced short palindromic repeats (CRISPR), and associated
proteins (Cas) comprise the CRISPR-Cas system, which confers adaptive immunity against …
proteins (Cas) comprise the CRISPR-Cas system, which confers adaptive immunity against …
Harnessing CRISPR-Cas9 immunity for genetic engineering
E Charpentier, LA Marraffini - Current opinion in microbiology, 2014 - Elsevier
Highlights•CRISPR-Cas is an RNA-mediated adaptive immune system against mobile
genomes.•RNA-programmable CRISPR-Cas9 enables targeted genome …
genomes.•RNA-programmable CRISPR-Cas9 enables targeted genome …
Endogenous CRISPR-Cas system-based genome editing and antimicrobials: review and prospects
Y Li, N Peng - Frontiers in microbiology, 2019 - frontiersin.org
CRISPR-Cas systems adapt “memories” via spacers from viruses and plasmids to develop
adaptive immunity against mobile genetic elements. Mature CRISPR RNAs guide CRISPR …
adaptive immunity against mobile genetic elements. Mature CRISPR RNAs guide CRISPR …
The revolution continues: newly discovered systems expand the CRISPR-Cas toolkit
CRISPR-Cas systems defend prokaryotes against bacteriophages and mobile genetic
elements and serve as the basis for revolutionary tools for genetic engineering. Class 2 …
elements and serve as the basis for revolutionary tools for genetic engineering. Class 2 …
Exploiting CRISPR/C as systems for biotechnology
TR Sampson, DS Weiss - Bioessays, 2014 - Wiley Online Library
The Cas9 endonuclease is the central component of the Type II CRISPR/Cas system, a
prokaryotic adaptive restriction system against invading nucleic acids, such as those …
prokaryotic adaptive restriction system against invading nucleic acids, such as those …
[HTML][HTML] Bacterial CRISPR/Cas DNA endonucleases: A revolutionary technology that could dramatically impact viral research and treatment
EM Kennedy, BR Cullen - Virology, 2015 - Elsevier
CRISPR/Cas systems mediate bacterial adaptive immune responses that evolved to protect
bacteria from bacteriophage and other horizontally transmitted genetic elements. Several …
bacteria from bacteriophage and other horizontally transmitted genetic elements. Several …
Diversity of CRISPR-Cas immune systems and molecular machines
R Barrangou - Genome biology, 2015 - Springer
Bacterial adaptive immunity hinges on CRISPR-Cas systems that provide DNA-encoded,
RNA-mediated targeting of exogenous nucleic acids. A plethora of CRISPR molecular …
RNA-mediated targeting of exogenous nucleic acids. A plethora of CRISPR molecular …
The roles of CRISPR–Cas systems in adaptive immunity and beyond
R Barrangou - Current opinion in immunology, 2015 - Elsevier
Highlights•CRISPR–Cas systems provide adaptive immunity against viruses in bacteria and
archaea.•Small-interfering RNAs guide nucleases for specific cleavage of complementary …
archaea.•Small-interfering RNAs guide nucleases for specific cleavage of complementary …
CRISPR–Cas systems: beyond adaptive immunity
The discovery of CRISPR–Cas (clustered, regularly interspaced short palindromic repeats–
CRISPR-associated proteins) adaptive immune systems in prokaryotes has been one of the …
CRISPR-associated proteins) adaptive immune systems in prokaryotes has been one of the …
CRISPR/Cas, the immune system of bacteria and archaea
P Horvath, R Barrangou - Science, 2010 - science.org
Microbes rely on diverse defense mechanisms that allow them to withstand viral predation
and exposure to invading nucleic acid. In many Bacteria and most Archaea, clustered …
and exposure to invading nucleic acid. In many Bacteria and most Archaea, clustered …