Effect of polygenic risk scores on depression in childhood trauma

WJ Peyrot, Y Milaneschi, A Abdellaoui… - The British Journal of …, 2014 - cambridge.org
BackgroundResearch on gene× environment interaction in major depressive disorder
(MDD) has thus far primarily focused on candidate genes, although genetic effects are …

Gene–environment interactions in common mental disorders: an update and strategy for a genome-wide search

R Uher - Social psychiatry and psychiatric epidemiology, 2014 - Springer
A decade of research has demonstrated the explanatory potential of interplay between
genetic variants and environmental factors in the development of common mental disorders …

Polygenic risk for autism, attention-deficit hyperactivity disorder, schizophrenia, major depressive disorder, and neuroticism is associated with the experience of …

A Ratanatharathorn, KC Koenen, LB Chibnik… - Molecular …, 2021 - nature.com
People who experience childhood abuse are at increased risk of mental illness. Twin
studies suggest that inherited genetic risk for mental illness may account for some of these …

Transgenerational epigenetic influences of paternal environmental exposures on brain function and predisposition to psychiatric disorders

S Yeshurun, AJ Hannan - Molecular Psychiatry, 2019 - nature.com
In recent years, striking new evidence has demonstrated non-genetic inheritance of
acquired traits associated with parental environmental exposures. In particular, this …

From nature versus nurture, via nature and nurture, to gene× environment interaction in mental disorders

AK Wermter, M Laucht, BG Schimmelmann… - European child & …, 2010 - Springer
It is now generally accepted that complex mental disorders are the results of interplay
between genetic and environmental factors. This holds out the prospect that by studying G× …

Child maltreatment: an intergenerational cascades model of risk processes potentiating child psychopathology

J Russotti, JM Warmingham, ED Handley… - Child Abuse & …, 2021 - Elsevier
Background Child maltreatment poses substantial risk for compromised mental health in
children. Further, child abuse and neglect are potentiated within a cascade of …

Genetic and environmental risk factors associated with trajectories of depression symptoms from adolescence to young adulthood

ASF Kwong, JA López-López, G Hammerton… - JAMA Network …, 2019 - jamanetwork.com
Importance Less favorable trajectories of depressive mood from adolescence to early
adulthood are associated with current and later psychopathology, impaired educational …

The relationship between childhood maltreatment and mental health problems: coping strategies and social support act as mediators

Y Su, X Meng, G Yang, C D'Arcy - BMC psychiatry, 2022 - Springer
Background Childhood maltreatment significantly increases the risk of developing mental
health problems in adolescence and adulthood. The present study examines if coping …

Nature, nurture and mental disorder: old concepts in the new millennium

B Cooper - The British Journal of Psychiatry, 2001 - cambridge.org
BackgroundEvidence from twin and adoption studies has highlighted the importance of
gene-environment interaction in the aetiology of mental disorders, and advances in …

[HTML][HTML] Safe, stable, nurturing relationships break the intergenerational cycle of abuse: A prospective nationally representative cohort of children in the United …

SR Jaffee, L Bowes, I Ouellet-Morin, HL Fisher… - Journal of Adolescent …, 2013 - Elsevier
Purpose To identify contextual and interpersonal factors that distinguish families in which the
intergenerational transmission of maltreatment is maintained from families in which the cycle …