Telomerase RNA has been uncovered as a component of the telomerase enzyme, which
acts as a reverse transcriptase and maintains the length of telomeres in proliferated …

Human telomerase catalytic subunit hTERT is subjected to alternative splicing results in loss
of its function and leads to decrease of telomerase activity. However, very little is known …

Eight human and six chicken novel alternatively spliced (AS) variants of telomerase reverse
transcriptase (TERT) were identified, including a human variant (Δ4-13) containing an in …

Telomerase is a reverse transcriptase that adds telomeric repeats to chromosomal ends. In
most normal human somatic cells, telomerase is repressed and telomeres progressively …

The human telomerase reverse transcriptase (hTERT) is the catalytic subunit of the enzyme
telomerase which is responsible for telomeric maintenance and extension. Using RNA …

Background Telomerase is a reverse transcriptase that maintains the telomeres of linear
chromosomes and preserves genomic integrity. The core components are a catalytic protein …

The expression of the catalytic subunit (hTERT) represents the limiting factor for telomerase
activity. In transfection studies, high level of activity of hTERT promoter is found, whereas low …

Telomeres, the repetitive sequences at chromosomal ends, protect intact chromosomes.
Telomeres progressively shorten through successive rounds of cell divisions, and critically …

Telomerase plays a critical role in stem cell function and tissue regeneration that depends
on its ability to elongate telomeres. For nearly two decades, it turned out that TERT regulates …

Telomerase—a complex ribonucleoprotein enzyme—synthesizes telomeric repeats to avoid
telomere loss that accompanies cell division and chromosomal replication. Expression of …