The quality control of protein homoeostasis deteriorates with aging, causing the
accumulation of misfolded proteins and neurodegeneration. Thus, in AD (Alzheimer's …

Aging is characterized by a significant decline of metabolic and hormonal functions, which
often facilitates the onset of severe age-associated pathologies. One outstanding example of …

Cellular and molecular processes leading to abnormal accumulation of β amyloid in the
brain are slowly being uncovered. A potential involvement of insulin and insulin-like growth …

Although increased lifespan is associated with reduced insulin signaling, insulin signaling is
essential for neuronal development and survival. Insulin resistance is central to Type II …

Background The insulin/IGF1 signalling (IIS) pathways are involved in longevity regulation
and are dysregulated in neurons in Alzheimer's disease (AD). We previously showed …

The normal on and off switching of the PI3-K (phosphoinositide 3-kinase)/Akt pathway,
particularly by its major activators insulin and IGF-1 (insulin-like growth factor-1), is a …

The 'amyloid cascade hypothesis' proposes that disturbances in amyloid metabolism cause
Alzheimer's disease (AD). However, a comprehensive explanation of the mechanisms …

Alzheimer's disease (AD) has characteristic neuropathological abnormalities including
regionalized neurodegeneration, neurofibrillary tangles, amyloid beta (Aβ) deposition …

Growing evidence supports roles for brain insulin and insulin-like growth factor (IGF)
resistance and metabolic dysfunction in the pathogenesis of Alzheimer's disease (AD) …

Alzheimer's disease is the most common form of dementia among older people and is still
untreatable. While β-amyloid protein is recognized as the disease determinant with a pivotal …