Transcription factors (TF) bind DNA-target sites within promoters to activate gene
expression. TFs target their DNA-recognition sequences with high specificity by binding with …

Fate-changing transcription factors (TFs) scan chromatin to initiate new genetic programs
during cell differentiation and reprogramming. Yet the protein structure domains that allow …

The structure of promoter chromatin determines the ability of transcription factors (TFs) to
bind to DNA and therefore has a profound effect on the expression levels of genes …

To investigate the mechanisms by which transcription factors invade nucleosomal DNA and
replace histones at control elements, we have examined the response of the histone …

Nucleosomes cover most of the genome and are thought to be displaced by transcription
factors in regions that direct gene expression. However, the modes of interaction between …

Quantitative understanding of the principles regulating nucleosome occupancy on a
genome-wide level is a central issue in eukaryotic genomics. Here, we address this question …

Precise gene expression patterns are established by transcription factor (TFs) binding to
regulatory sequences. While these events occur in the context of chromatin, our …

The nucleosome represents a mechanical barrier to transcription that operates as a general
regulator of gene expression. We investigate how each nucleosomal component—the …

The compact structure of the nucleosome limits DNA accessibility and inhibits the binding of
most sequence-specific proteins. Nucleosomes are not randomly located on the DNA but …

Nucleosomes sterically occlude their wrapped DNA from interacting with many large protein
complexes. How proteins gain access to nucleosomal DNA target sites in vivo is not known …