ACE2 and a Traditional Chinese Medicine Formula NRICM101 Could Alleviate the Inflammation and Pathogenic Process of Acute Lung Injury

CH Lin - Physiology, 2024 - journals.physiology.org
The coronavirus disease 2019 (COVID-19) is a highly transmittable respiratory illness
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and acute lung …

[HTML][HTML] ACE2 and a Traditional Chinese Medicine Formula NRICM101 Could Alleviate the Inflammation and Pathogenic Process of Acute Lung Injury

CH Lin, YJ Chen, MW Lin, HJ Chang, XR Yang, CS Lin - Medicina, 2023 - mdpi.com
COVID-19 is a highly transmittable respiratory illness caused by SARS-CoV-2, and acute
lung injury (ALI) is the major complication of COVID-19. The challenge in studying SARS …

Role and mechanism of angiotensin-converting enzyme 2 in acute lung injury in coronavirus disease 2019

MY Liu, B Zheng, Y Zhang, JP Li - Chronic Diseases and …, 2020 - mednexus.org
Coronavirus disease 2019 is a major threat to public health globally. Though its
pathogenesis has not been fully elucidated, angiotensin-converting enzyme 2 (ACE2) has …

[HTML][HTML] Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease

JW Golden, CR Cline, X Zeng, AR Garrison, BD Carey… - JCI insight, 2020 - ncbi.nlm.nih.gov
The emergence of SARS-CoV-2 has created an international health crisis, and small animal
models mirroring SARS-CoV-2 human disease are essential for medical countermeasure …

Lisinopril increases lung ACE2 levels and SARS-CoV-2 viral load and decreases inflammation but not disease severity in experimental COVID-19

Y Silva-Santos, RL Pagni, THM Gamon… - Frontiers in …, 2024 - frontiersin.org
COVID-19 causes more severe and frequently fatal disease in patients with pre-existing
comorbidities such as hypertension and heart disease. SARS-CoV-2 virus enters host cells …

[HTML][HTML] Ace2 and innate immunity in the regulation of SARS-CoV-2-induced acute lung injury: A review

L Qu, C Chen, T Yin, Q Fang, Z Hong, R Zhou… - International journal of …, 2021 - mdpi.com
Despite the protracted battle against coronavirus acute respiratory infection (COVID-19) and
the rapid evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Zang Siwei Qingfei Mixture Alleviates Inflammatory Response to Attenuate Acute Lung Injury by the ACE2/NF-κB Signaling Pathway in Mice.

S Lei, S Wu - Combinatorial Chemistry & High Throughput …, 2023 - europepmc.org
Background Acute lung injury (ALI) is a serious lung disease characterized by acute and
severe inflammation. Upregulation of ACE2 and inhibition of the NF-κB signaling pathway …

ACE2 exhibits protective effects against LPS-induced acute lung injury in mice by inhibiting the LPS-TLR4 pathway

R Ye, Z Liu - Experimental and molecular pathology, 2020 - Elsevier
This study aimed to investigate the protective effect of angiotensin converting enzyme 2
(ACE2) on lipopolysaccharide (LPS)-induced acute lung injury (ALI). After generating ALI …

[HTML][HTML] The two-way switch role of ACE2 in the treatment of novel coronavirus pneumonia and underlying comorbidities

XC Pang, HX Zhang, Z Zhang, S Rinkiko, YM Cui… - Molecules, 2020 - mdpi.com
December 2019 saw the emergence of the coronavirus disease 2019 (COVID-19), caused
by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which has spread …

Development and Characterization of a novel humanized ACE2 mouse model to study the pathogenesis of viral lung infection by variable SARS-CoV-2 strains

CY Choi, J Villano, A Pekosz, H Jia - The Journal of Immunology, 2023 - journals.aai.org
Despite global efforts to end the pandemic of COVID19 which has claimed millions of lives in
the past few years, there is no sign of the ending in foresee near future. One of the obstacles …