The role of T cell populations in immune control of Trypanosoma cruzi infection and
subsequent development of disease has been examined using gene knockout mice …

Infection with Trypanosoma cruzi results in the development of both type 1 and type 2
patterns of cytokine responses during acute and chronic stages of infection. To investigate …

The role of CD8+ T cells in immune control of Trypanosoma cruzi infection in mice was
examined by using in vivo depletion of CD8+ T cells with antibodies. Both the resistant …

Mice injected with monoclonal antibody to the L3T4+ (CD4+) cell membrane surface
glycoprotein of T lymphocytes and immunized with antigens of Trypanosoma cruzi had …

C57BL/6 mice exhibit low parasitemias and often survive Trypanosoma cruzi infections,
whereas C3H (He) mice die during the acute phase with relatively high parasitemias. The …

Immune control of the protozoan parasite Trypanosoma cruzi requires the activation of both
CD4+ and CD8+ T cells. We recently identified two T. cruzi trans-sialidase peptides that are …

T lymphocytes provide a major line of defence against many protozoan parasites. The aim of
this work was to determine the role of T‐cell helper/inducer subset (T h/i) in the resistance to …

The life cycle of the protozoan parasite Trypanosoma cruzi in mammalian hosts includes
both non‐dividing trypomastigote forms which circulate in the blood and replicating …

Mice lacking CD4 and/or CD8 gene expression, generated by embryonic stem-cell
technology, were used to study the role of CD4+ and CD8+ cells in the resistance to the …

Recent in vivo depletion studies in mice demonstrated that CD8+ T cells play a critical role in
acute resistance to experimental Trypanosoma cruzi infections. As part of efforts to …