FTO-stabilized miR-139–5p targets ZNF217 to suppress prostate cancer cell malignancies by inactivating the PI3K/Akt/mTOR signal pathway
B Azhati, A Reheman, D Dilixiati, M Rexiati - Archives of Biochemistry and …, 2023 - Elsevier
As one of the most important demethylases for RNA N6-methyladenosine (m6A)
modifications, fat mass and obesity-associated protein (FTO) plays anti-cancer role during …
modifications, fat mass and obesity-associated protein (FTO) plays anti-cancer role during …
N6-methyladenosine demethylase FTO suppressed prostate cancer progression by maintaining CLIC4 mRNA stability
L Zou, W Chen, X Zhou, T Yang, J Luo, Z Long… - Cell Death …, 2022 - nature.com
The fat mass and obesity-associated protein (FTO) is an N6-Methyladenosine (m6A)
demethylase, which has been revealed to play critical roles in tumorigenesis. However, its …
demethylase, which has been revealed to play critical roles in tumorigenesis. However, its …
m6A RNA demethylase FTO promotes the growth, migration and invasion of pancreatic cancer cells through inhibiting TFPI-2
W Wang, Y He, LL Zhai, LJ Chen, LC Yao, L Wu… - Epigenetics, 2022 - Taylor & Francis
Pancreatic cancer (PC) is one of the most fatal cancers with a very poor prognosis. Here, we
found that N6-methyladenosine (m6A) RNA demethylase fat mass and obesity-related …
found that N6-methyladenosine (m6A) RNA demethylase fat mass and obesity-related …
The FTO m6A demethylase inhibits the invasion and migration of prostate cancer cells by regulating total m6A levels
K Zhu, Y Li, Y Xu - Life Sciences, 2021 - Elsevier
Abstract Aims N6-Methyladenosine (m 6 A) is the most frequent posttranscriptional
modification and plays important roles in tumorigenesis and metastasis. The roles of fat …
modification and plays important roles in tumorigenesis and metastasis. The roles of fat …
Demethyltransferase FTO alpha-ketoglutarate dependent dioxygenase (FTO) regulates the proliferation, migration, invasion and tumor growth of prostate cancer by …
S Li, L Cao - Bioengineered, 2022 - Taylor & Francis
ABSTRACT N6-Methyladenosine (m6A) is the most abundant modifications in human
messenger RNAs (mRNAs). This study aimed at investigating the function and mechanism …
messenger RNAs (mRNAs). This study aimed at investigating the function and mechanism …
The FTO mediated N6-methyladenosine modification of DDIT4 regulation with tumorigenesis and metastasis in prostate cancer
Y Zhao, X Hu, H Yu, H Sun, L Zhang, C Shao - Research, 2024 - spj.science.org
The progression of numerous malignancies has been linked to N6-methyladenosine (m6A)
alteration. However, the opposite trend of m6A levels in the development and metastasis of …
alteration. However, the opposite trend of m6A levels in the development and metastasis of …
FTO promotes proliferation and migration of bladder cancer via enhancing stability of STAT3 mRNA in an m6A-dependent manner
Z Sun, X Sun, G Qin, Y Li, G Zhou, X Jiang - Epigenetics, 2023 - Taylor & Francis
ABSTRACT N6-Methyladenosine (m6A) plays a key role in the occurrence and development
of various cancers. Fat mass and obesity‐associated protein (FTO) was is involved in …
of various cancers. Fat mass and obesity‐associated protein (FTO) was is involved in …
FTO facilitates cancer metastasis by modifying the m6A level of FAP to induce integrin/FAK signaling in non-small cell lung cancer
L Gao, A Wang, Y Chen, X Cai, Y Li, J Zhao… - Cell Communication and …, 2023 - Springer
Background Emerging evidence suggests the critical roles of N6-methyladenosine (m6A)
RNA modification in tumorigenesis and tumor progression. However, the role of m6A in non …
RNA modification in tumorigenesis and tumor progression. However, the role of m6A in non …
The potential role of N6-methyladenosine (m6A) demethylase fat mass and obesity-associated gene (FTO) in human cancers
J Wang, L Chen, P Qiang - OncoTargets and therapy, 2020 - Taylor & Francis
Abstract N6-methyladenosine (m6A) demethylase fat mass and obesity-associated gene
(FTO), previously recognized to be related with obesity and diabetes, was gradually …
(FTO), previously recognized to be related with obesity and diabetes, was gradually …
FTO suppresses glycolysis and growth of papillary thyroid cancer via decreasing stability of APOE mRNA in an N6-methyladenosine-dependent manner
J Huang, W Sun, Z Wang, C Lv, T Zhang… - Journal of Experimental …, 2022 - Springer
Abstract Background N6-methyladenosine (m6A) modification is the most common chemical
modification in mammalian mRNAs, and it plays important roles by regulating several …
modification in mammalian mRNAs, and it plays important roles by regulating several …