[HTML][HTML] Repurposing molnupiravir for COVID-19: the mechanisms of antiviral activity

AJW Yip, ZY Low, VTK Chow, SK Lal - Viruses, 2022 - mdpi.com
Molnupiravir is a β-d-N4-hydroxycytidine-5′-isopropyl ester (NHC) compound that exerts
antiviral activity against various RNA viruses such as influenza, SARS, and Ebola viruses …

[HTML][HTML] Antiviral activity of molnupiravir against COVID-19: a schematic review of evidences

S Singla, S Goyal - Bulletin of the National Research Centre, 2022 - Springer
Background The study was aimed at encapsulating the evidence of in vitro and in vivo
antiviral activities of molnupiravir and its active form against highly pathogenic SARS-CoV-2 …

What will be the role of molnupiravir in the treatment of COVID-19 infection?

A Vitiello, V Troiano, R La Porta - Drugs & Therapy Perspectives, 2021 - Springer
The global COVID-19 pandemic is currently underway. To date, there are approximately
4.55 million deaths and 219 million people infected [1]. The massive vaccination campaign …

Comprehensive review on molnupiravir in COVID-19: a novel promising antiviral to combat the pandemic

S Khiali, E Khani, SB Rouy… - Future Microbiology, 2022 - Taylor & Francis
Despite the progress in the management of COVID-19, effective oral antiviral agents are still
lacking. In the present review, the potential beneficial effects of molnupiravir in the …

[HTML][HTML] Molnupiravir and its antiviral activity against COVID-19

L Tian, Z Pang, M Li, F Lou, X An, S Zhu… - Frontiers in …, 2022 - frontiersin.org
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) constitutes a major worldwide public health threat …

[HTML][HTML] Molnupiravir: A versatile prodrug against SARS-CoV-2 variants

D Teli, P Balar, K Patel, A Sharma, V Chavda, L Vora - Metabolites, 2023 - mdpi.com
The nucleoside analog β-DN 4-hydroxycytidine is the active metabolite of the prodrug
molnupiravir and is accepted as an efficient drug against COVID-19. Molnupiravir targets the …

[HTML][HTML] Molnupiravir: from hope to epic fail?

D Focosi - Viruses, 2022 - mdpi.com
Molnupiravir has been the first oral antiviral authorized for COVID-19 outpatients, reporting
extraordinary sales and preserved in vitro efficacy against Omicron sublineages so far …

Molnupiravir: An antiviral drug against COVID-19

B Dave, KC Shah, MR Chorawala, N Shah, P Patel… - Archives of …, 2023 - Springer
Abstract SARS-CoV-2, the virus responsible for COVID-19, has caused numerous deaths
worldwide and poses significant challenges. Researchers have recently studied a new …

Developing a direct acting, orally available antiviral agent in a pandemic: the evolution of molnupiravir as a potential treatment for COVID-19

GR Painter, MG Natchus, O Cohen, W Holman… - Current opinion in …, 2021 - Elsevier
Highlights•Molnupiravir is a broad acting, oral antiviral versus SARS-CoV-2, flu, Ebola and
others.•Clinical development was greatly accelerated in response to the COVID19 …

Why molnupiravir fails in hospitalized patients

AN Brown, Y Lang, J Zhou, EJ Franco, KC Hanrahan… - Mbio, 2022 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
coronavirus disease 2019 (COVID-19), has radically altered daily life. Effective antiviral …