Many cell types transport vitamin C solely in its oxidized form, dehydroascorbic acid, through
facilitative glucose transporters. These cells accumulate large intracellular concentrations of …

The cellular accumulation of vitamin C, a substance critical to human physiology, is
mediated by transporters located at the cell membrane, and is regulated in a cell-specific …

It is unknown whether ascorbate alone (vitamin C), its oxidized metabolite dehydroascorbic
acid alone, or both species are transported into human cells. This problem was addressed …

Specialized cells transport vitamin C in its reduced form using sodium‐dependent
cotransporters (SVCT1 and SVCT2). Additionally, different cells transport the oxidized form …

Human tumors may contain high concentrations of ascorbic acid, but little is known about
how they acquire the vitamin. Certain specialized cells can transport ascorbic acid directly …

We investigated the transport pathways available for the uptake of vitamin C in the human
placental choriocarcinoma cell line, JAR. These cells were found to possess the capacity to …

We performed a detailed kinetic analysis of the uptake of dehydroascorbic acid by HL-60
cells under experimental conditions that enabled the differentiation of dehydroascorbic acid …

Cellular ascorbic acid accumulation occursin vitro by two distinct mechanisms: transport of
ascorbate itself or transport and subsequent intracellular reduction of its oxidized product …

Human myeloid leukemia cells (HL-60) transport only the oxidized form of vitamin C
(dehydroascorbic acid) and accumulate the vitamin in the reduced form, ascorbic acid. We …

As the initial step in the use of fibroblasts as a model system for 'in situ kinetics', ascorbic
acid (vitamin C) accumulation in normal human fibroblasts was investigated for the first time …