Reactive oxygen species have been implicated in the pathophysiology of renal ischemia
reperfusion (I/R) injury. The pineal secretory product melatonin is known to be a potent free …

Oxygen free radicals are considered to be important components involved in the
pathophysiological tissue alterations observed during ischemia–reperfusion (I/R). In this …

The pathophysiologic mechanisms leading to acute ischemic renal failure are not
completely understood. Melatonin, a compound with well‐known antioxidant properties …

Introduction. We investigated the roles of melatonin (a powerful antioxidant, iNOS inhibitor,
and a scavenger of peroxynitrite) and 1400W (a strong and selective inhibitor of inducible …

Reactive oxygen species (ROS) were shown to contribute to the cellular damage induced by
ischemia-reperfusion. The purpose of this study was to investigate and compare the …

BACKGROUND: We studied whether melatonin is able to reduce organ damage during
renal ischemia/reperfusion via its effects on the oxidative response in early and late …

Reactive oxygen metabolites play important roles in ischemia/reperfusion (I/R) injury in
several systems. The aim of this study was to investigate the role of melatonin against I/R …

The pineal hormone melatonin has been reported to protect tissue from oxidative damage.
This study was designed to determine whether melatonin could prevent cell events leading …

Background Melatonin is released by pineal gland and maintains circadian rhythm in the
body. It has been reported as renoprotective agent because of its antioxidant property …

Recent studies show that melatonin reduces the blood pressure (BP) and
ischemia/reperfusion (I/R)-induced damage. This study was designed to investigate the …