A bispecific antibody targeting RBD and S2 potently neutralizes SARS-CoV-2 Omicron and other variants of concern

M Yuan, X Chen, Y Zhu, X Dong, Y Liu, Z Qian… - Journal of …, 2022 - Am Soc Microbiol
Emerging severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) variants,
especially the Omicron variant, have impaired the efficacy of existing vaccines and most …

Defining a de novo non-RBM antibody as RBD-8 and its synergistic rescue of immune-evaded antibodies to neutralize Omicron SARS-CoV-2

X Rao, R Zhao, Z Tong, S Guo… - Proceedings of the …, 2023 - National Acad Sciences
Currently, monoclonal antibodies (MAbs) targeting the SARS-CoV-2 receptor binding
domain (RBD) of spike (S) protein are classified into seven classes based on their binding …

A novel bispecific antibody dual-targeting approach for enhanced neutralization against fast-evolving SARS-CoV-2 variants

JW Kim, HJ Kim, K Heo, Y Lee, HJ Jang… - Frontiers in …, 2023 - frontiersin.org
Introduction The emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) variants has caused unprecedented health and socioeconomic crises, necessitating …

[PDF][PDF] Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern

W Li, Y Chen, J Prévost, I Ullah, M Lu, SY Gong… - Cell reports, 2022 - cell.com
Emerging variants of concern for the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) can transmit more efficiently and partially evade protective immune …

Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern

H Cho, KK Gonzales-Wartz, D Huang, M Yuan… - Science translational …, 2021 - science.org
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
of concern threatens the efficacy of existing vaccines and therapeutic antibodies and …

Cross-neutralization of emerging SARS-CoV-2 variants of concern by antibodies targeting distinct epitopes on spike

S Changrob, Y Fu, JJ Guthmiller, PJ Halfmann, L Li… - Mbio, 2021 - Am Soc Microbiol
Several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have
arisen that exhibit increased viral transmissibility and partial evasion of immunity induced by …

Combating the SARS-CoV-2 Omicron (BA. 1) and BA. 2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies

Y Wang, X Zhang, Y Ma, Y Wang, W Zhan, Q Zheng… - Cell Discovery, 2022 - nature.com
The highly mutated and transmissible Omicron (BA. 1) and its more contagious lineage BA.
2 have provoked serious concerns over their decreased sensitivity to the current COVID-19 …

Defining a highly conserved cryptic epitope for antibody recognition of SARS-CoV-2 variants

A Hao, W Song, C Li, X Zhang, C Tu, X Wang… - … and Targeted Therapy, 2023 - nature.com
In recent months, additional Omicron variants of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), including the BA. 5 sublineage BF. 7 and BQ. 1.1 and the BA …

Site of vulnerability on SARS-CoV-2 spike induces broadly protective antibody against antigenically distinct Omicron subvariants

S Changrob, PJ Halfmann, H Liu… - The Journal of …, 2023 - Am Soc Clin Investig
The rapid evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Omicron variants has emphasized the need to identify antibodies with broad neutralizing …

A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD

X Wang, A Hu, X Chen, Y Zhang, F Yu, S Yue… - … and Targeted Therapy, 2022 - nature.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global
pandemic of novel coronavirus disease (COVID-19). The neutralizing monoclonal …