Reduction of conditioned fear expression by extinction underlies cue exposure therapies
that treat anxiety disorders. Extinction is context-specific. Renewal, for example, is the …

In recent studies, inactivation of the dorsal hippocampus before the retrieval of extinguished
fear memories disrupted the context-dependent expression of these memories. In the …

Fear extinction, the reduction of fear by repeated exposure to the object of fear, is a crucial
paradigm of inhibitory learning and the acknowledged preclinical model for behavior …

Fear extinction is the decrease in conditioned fear responses that normally occurs when a
conditioned stimulus (CS) is repeatedly presented in the absence of the aversive …

Fear extinction forms a new memory but does not erase the original fear memory. Exposure
to novelty facilitates transfer of short-term extinction memory to long-lasting memory …

Impairment in fear extinction is widely viewed as a major contributor to, or even an
underlying mechanism of, the pathogenesis of anxiety disorders and PTSD. Children with …

Extinction of classical fear conditioning is thought to involve activity‐dependent potentiation
of synaptic transmission in the medial prefrontal cortex (mPFC), resulting in the inhibition of …

Decades of behavioral studies have confirmed that extinction does not erase classically
conditioned fear memories. For this reason, research efforts have focused on the …

Recent studies implicate the hippocampus in contextual memory retrieval. The present
experiments explore this possibility by examining the impact of reversible inactivation of the …

Anxiety disorders are commonly treated with exposure-based therapies that rely on
extinction of conditioned fear. Persistent fear and anxiety following exposure therapy could …