Inhibitors of adenosine consuming parasites through polymer-assisted N-acylation of N6-substituted 5′-amino-5′-deoxyadenosines
V Zohrabi-Kalantari, P Heidler, M Kaiser, R Brun… - Molecular …, 2010 - Springer
A series of 30 adenosine derivatives with three different substituents at the N 6-position were
prepared in order to evaluate their potential to inhibit the pathogenic protozoa Plasmodium …
prepared in order to evaluate their potential to inhibit the pathogenic protozoa Plasmodium …
Inhibitors of adenosine consuming parasites through polymer-assisted solution phase synthesis of lipophilic 5′-amido-5′-deoxyadenosine derivatives
P Heidler, V Zohrabi-Kalantari, M Kaiser, R Brun… - Bioorganic & Medicinal …, 2009 - Elsevier
Given the more or less global spread of multidrug-resistant plasmodia, structurally diverse
starting points for the development of chemotherapeutic agents for the treatment of malaria …
starting points for the development of chemotherapeutic agents for the treatment of malaria …
Antimalarial activity of N6-substituted adenosine derivatives. Part 3
C Herforth, J Wiesner, P Heidler, S Sanderbrand… - Bioorganic & medicinal …, 2004 - Elsevier
A series of novel 3′-amido-3′-deoxy-N6-(1-naphthylmethyl) adenosines was synthesized
applying a polymer-assisted solution phase (PASP) protocol and was tested for anti-malarial …
applying a polymer-assisted solution phase (PASP) protocol and was tested for anti-malarial …
2,N6-Disubstituted Adenosine Analogs with Antitrypanosomal and Antimalarial Activities
B Rodenko, AM van der Burg, MJ Wanner… - Antimicrobial agents …, 2007 - Am Soc Microbiol
ABSTRACT A library of 2, N6-disubstituted adenosine analogs was synthesized and the
analogs were tested for their antiprotozoal activities. It was found that 2-methoxy and 2 …
analogs were tested for their antiprotozoal activities. It was found that 2-methoxy and 2 …
Anti-malarial activity of N6-substituted adenosine derivatives. Part I
A Golisade, J Wiesner, C Herforth, H Jomaa… - Bioorganic & medicinal …, 2002 - Elsevier
The synthesis and biological evaluation of novel N6-substituted adenosine derivatives is
reported. The first series of compounds was obtained using an established procedure for the …
reported. The first series of compounds was obtained using an established procedure for the …
Synthesis and Antimalarial Activity of Novel N 6-Substituted Adenosine Derivatives
PH Heidler, C Herforth, A Link - Nucleosides, Nucleotides and …, 2003 - Taylor & Francis
The results show that eg, N6-(1-naphthylmethyl)-5 0-deoxy-5 0-(amido)-adenosines as well
as N6-(4-phenylbenzyl)-5 0-deoxy-5 0-(amido) adenosines display significant activity …
as N6-(4-phenylbenzyl)-5 0-deoxy-5 0-(amido) adenosines display significant activity …
Antimalarial Activity of N6-Substituted Adenosine Derivatives (Part 2)
C Herforth, J Wiesner, S Franke… - Journal of …, 2002 - ACS Publications
We have investigated the in vitro antimalarial activity of a new series of adenosine
derivatives. The results show that N 6-(1-naphthylmethyl)-5 '-deoxy-5 '-(amido) adenosines …
derivatives. The results show that N 6-(1-naphthylmethyl)-5 '-deoxy-5 '-(amido) adenosines …
Solid phase synthesis and antiprotozoal evaluation of di-and trisubstituted 5′-carboxamidoadenosine analogues
B Rodenko, RJ Detz, VA Pinas, C Lambertucci… - Bioorganic & medicinal …, 2006 - Elsevier
The rapid increase of resistance to drugs commonly used in the treatment of tropical
diseases such as malaria and African sleeping sickness calls for the prompt development of …
diseases such as malaria and African sleeping sickness calls for the prompt development of …
Synthesis of a series of N6-substituted adenosines with activity against trypanosomatid parasites
A Link, P Heidler, M Kaiser, R Brun - European journal of medicinal …, 2009 - Elsevier
The involvement of purine salvage in the accumulation of current trypanocidal drugs is
important for the treatment of African sleeping sickness. The substrate specificity of essential …
important for the treatment of African sleeping sickness. The substrate specificity of essential …
Synthesis of 3′-amino-3′-deoxyadenosine derivatives as potential drugs for the treatment of malaria
J Soenens, G François, EV den Eeckhout… - … Nucleotides & Nucleic …, 1995 - Taylor & Francis
Synthesis of 3′-Amino-3′-deoxyadenosine Derivatives as Potential Drugs for the Treatment of
Malaria Page 1 NUCLEOSIDES & NUCLEOTIDES, 14(3-5), 409-41 1 (1995) SYNTHESIS OF …
Malaria Page 1 NUCLEOSIDES & NUCLEOTIDES, 14(3-5), 409-41 1 (1995) SYNTHESIS OF …