The kallikrein-kinin system is involved in a variety of physiological and pathological
processes. Components of this system, identified in rat and human brains, can be altered in …

The Kallikrein-Kinin System (KKS) has been associated to inflammatory and immunogenic
responses in the peripheral and central nervous system by the activation of two receptors …

Although numerous inflammation pathways have been implicated in Alzheimer's disease,
the involvement of the kallikrein–kinin system is still under investigation. We anatomically …

The present study shows that rat brain contains a kinin-forming activity which is
distinguishable from plasma kallikrein. Kinin-forming activity was found in an acetone …

Decreased cerebral blood flow and blood-brain barrier disruption are features of Alzheimer's
disease (AD). The plasma kallikrein-kinin system modulates cerebrovascular tone through …

The plaques associated with Alzheimer's disease are formed as a result of the aggregation
of Aβ peptides, which vary in length from 38 to 43 amino acids. The 1-40 peptide is the most …

The nervous system and peripheral tissues in mammals contain a large number of
biologically active peptides and proteases that function as neurotransmitters or …

The mediatory role of kinins in both acute and chronic inflammation within nervous tissues
has been widely described. Bradykinin, the major representative of these bioactive peptides …

Alzheimer's disease (AD) is characterized by the presence of proteinaceous brain deposits,
brain atrophy, vascular dysfunction, and chronic inflammation. Along with cerebral …

Bradykinin is a proinflammatory factor that mediates angioedema and inflammation in many
diseases. It is a key player in some types of hereditary angioedema and is involved in septic …