Canine coronavirus activates aryl hydrocarbon receptor during in vitro infection

C Cerracchio, F Serra, MG Amoroso, F Fiorito - Viruses, 2022 - mdpi.com
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that interacts
with substrates, including microbial metabolites. Recent advances reveal that AhR is …

Aryl hydrocarbon receptor is a proviral host factor and a candidate pan-SARS-CoV-2 therapeutic target

J Shi, T Du, J Wang, C Tang, M Lei, W Yu, Y Yang… - Science …, 2023 - science.org
The emergence of a series of SARS-CoV-2 variants has necessitated the search for broad-
spectrum antiviral targets. The aryl hydrocarbon receptor (AhR) senses tryptophan …

Aryl hydrocarbon receptor activation alters immune cell populations in the lung and bone marrow during coronavirus infection

AM Healey, KN Fenner, CT O'Dell… - American Journal of …, 2024 - journals.physiology.org
Respiratory viral infections are one of the major causes of illness and death worldwide.
Symptoms associated with respiratory infections can range from mild to severe, and there is …

AHR signaling is induced by infection with coronaviruses

F Giovannoni, Z Li, F Remes-Lenicov… - Nature …, 2021 - nature.com
Coronavirus infection in humans is usually associated to respiratory tract illnesses, ranging
in severity from mild to life-threatening respiratory failure. The aryl hydrocarbon receptor …

[HTML][HTML] A potential role for AHR in SARS-CoV-2 pathology

F Giovannoni, Z Li, CC Garcia, FJ Quintana - Research Square, 2020 - ncbi.nlm.nih.gov
Coronavirus infection is associated to life-threatening respiratory failure. The aryl
hydrocarbon receptor (AHR) was recently identified as a host factor for Zika and dengue …

Murine coronavirus infection activates the aryl hydrocarbon receptor in an indoleamine 2, 3-dioxygenase-independent manner, contributing to cytokine modulation …

ME Grunewald, MG Shaban, SR Mackin… - Journal of …, 2020 - Am Soc Microbiol
The aryl hydrocarbon receptor (AhR) is a cytoplasmic receptor/transcription factor that
modulates several cellular and immunological processes following activation by pathogen …

When AHR signaling pathways meet viral infections

J Hu, Y Ding, W Liu, S Liu - Cell Communication and Signaling, 2023 - Springer
Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcriptional factor widely
expressed among immune, epithelial, endothelial and stromal cells in barrier tissues. It can …

Role of aryl hydrocarbon receptors in infection and inflammation

L Xu, L Lin, N Xie, W Chen, W Nong, R Li - Frontiers in Immunology, 2024 - frontiersin.org
The aryl hydrocarbon receptor (AhR) is a transcription factor that is activated by various
ligands, including pollutants, microorganisms, and metabolic substances. It is expressed …

SARS-CoV-2-induced lung pathology: AHR as a candidate therapeutic target

F Giovannoni, FJ Quintana - Cell Research, 2021 - nature.com
The aryl hydrocarbon receptor (AHR) is activated by multiple viruses to evade the host
immune response, a strategy exploited in pre-clinical models to limit the replication of Zika …

Aryl hydrocarbon receptor: a new player of pathogenesis and therapy in cardiovascular diseases

T Yi, J Wang, K Zhu, Y Tang, S Huang… - BioMed research …, 2018 - Wiley Online Library
The aryl hydrocarbon receptor (AhR) is a DNA binding protein that acts as a nuclear
receptor mediating xenobiotic metabolism and environmental responses. Owing to the …