Friends or foes? The knowns and unknowns of natural killer cell biology in COVID-19 and other coronaviruses in July 2020

C Manickam, S Sugawara, RK Reeves - PLoS pathogens, 2020 - journals.plos.org
The COVID-19 pandemic has caused more than 575,000 deaths worldwide as of mid-July
2020 and still continues globally unabated. Immune dysfunction and cytokine storm …

[HTML][HTML] Natural killer cells in SARS-CoV-2 infection: pathophysiology and therapeutic implications

C Di Vito, F Calcaterra, N Coianiz, S Terzoli… - Frontiers in …, 2022 - frontiersin.org
Natural Killer (NK) cells are lymphocytes of the innate immunity that play a crucial role in the
control of viral infections in the absence of a prior antigen sensitization. Indeed, they display …

Flattening the COVID-19 curve with natural killer cell based immunotherapies

M Market, L Angka, AB Martel, D Bastin… - Frontiers in …, 2020 - frontiersin.org
Natural Killer (NK) cells are innate immune responders critical for viral clearance and
immunomodulation. Despite their vital role in viral infection, the contribution of NK cells in …

NK cells in COVID-19—from disease to vaccination

Q Hammer, A Cuapio, J Bister… - Journal of Leukocyte …, 2023 - academic.oup.com
Natural killer cells participate in the host innate immune response to viral infection.
Conversely, natural killer cell dysfunction and hyperactivation can contribute to tissue …

Exploring the utility of NK cells in COVID-19

X Deng, H Terunuma, M Nieda - Biomedicines, 2022 - mdpi.com
Coronavirus disease 2019 (COVID-19) can manifest as acute respiratory distress syndrome
and is associated with substantial morbidity and mortality. Extensive data now indicate that …

NK cells: A double edge sword against SARS-CoV-2

E Masselli, M Vaccarezza, C Carubbi, G Pozzi… - Advances in biological …, 2020 - Elsevier
Natural killer (NK) cells are pivotal effectors of the innate immunity protecting an individual
from microbes. They are the first line of defense against invading viruses, given their …

Natural killer cell exhaustion in SARS-CoV-2 infection

J Gallardo-Zapata, C Maldonado-Bernal - Innate Immunity, 2022 - journals.sagepub.com
At the end of 2019, an outbreak of a severe respiratory disease occurred in Wuhan China,
and an increase in cases of unknown pneumonia was alerted. In January 2020, a new …

Natural killer cells play an important role in virus infection control: Antiviral mechanism, subset expansion and clinical application

W Zuo, X Zhao - Clinical Immunology, 2021 - Elsevier
With the global spread of coronavirus disease 2019 (COVID-19), the important role of
natural killer (NK) cells in the control of various viral infections attracted more interest, via …

Natural killer cells in antiviral immunity

NK Björkström, B Strunz, HG Ljunggren - Nature Reviews Immunology, 2022 - nature.com
Natural killer (NK) cells play an important role in innate immune responses to viral infections.
Here, we review recent insights into the role of NK cells in viral infections, with particular …

Natural killer cell activation related to clinical outcome of COVID-19

C Maucourant, I Filipovic, A Ponzetta, S Aleman… - medRxiv, 2020 - medrxiv.org
Understanding innate immune responses in COVID-19 is important for deciphering
mechanisms of host responses and interpreting disease pathogenesis. Natural killer (NK) …