Characterizing cognitive aging in humans with links to animal models

GE Alexander, L Ryan, D Bowers, TC Foster… - Frontiers in Aging …, 2012 - frontiersin.org
With the population of older adults expected to grow rapidly over the next two decades, it
has become increasingly important to advance research efforts to elucidate the mechanisms …

Assessing cognitive decline in the aging brain: Lessons from rodent and human studies

DVC Brito, F Esteves, AT Rajado, N Silva, I Araújo… - npj Aging, 2023 - nature.com
As life expectancy continues to increase worldwide, age-related dysfunction will largely
impact our societies in the future. Aging is well established to promote the deterioration of …

[图书][B] Animal models of human cognitive aging

JL Bizon, AG Woods - 2009 - Springer
Because of significant improvements in health style and medical science, an increasingly
large number of individuals are living to advanced ages in the United States and other …

Mindspan: lessons from rat models of neurocognitive aging

M Gallagher, AM Stocker, MT Koh - ILAR journal, 2011 - academic.oup.com
Research on the biology of aging seeks to enhance understanding of basic mechanisms
and thus support improvements in outcomes throughout the lifespan, including longevity …

Structural imaging measures of brain aging

SN Lockhart, C DeCarli - Neuropsychology review, 2014 - Springer
During the course of normal aging, biological changes occur in the brain that are associated
with changes in cognitive ability. This review presents data from neuroimaging studies of …

Neuroimaging of healthy cognitive aging

NA Dennis, R Cabeza - The handbook of aging and cognition, 2011 - taylorfrancis.com
Cognitive aging research and theory has, until recently, been based upon behavioral
measures of cognitive performance such as response time and accuracy. Results from …

The shifting architecture of cognition and brain function in older adulthood

RN Spreng, GR Turner - Perspectives on Psychological …, 2019 - journals.sagepub.com
Cognitive aging is often described in the context of loss or decline. Emerging research
suggests that the story is more complex, with older adults showing both losses and gains in …

Human neuroscience and the aging mind: a new look at old problems

PA Reuter-Lorenz, DC Park - Journals of Gerontology Series B …, 2010 - academic.oup.com
In this article, marking the 65th anniversary of the Journal of Gerontology, we offer a broad-
brush overview of the new synthesis between neuroscientific and psychological approaches …

Individual differences in the cognitive and neurobiological consequences of normal aging

PR Rapp, DG Amaral - Trends in neurosciences, 1992 - cell.com
Defining the neural basis of age-related cognitive dysfunction is a major goal of current
research on aging. Compelling evidence from laboratory animals and humans indicates that …

Cerebral aging: integration of brain and behavioral models of cognitive function

DC Park, TA Polk, JA Mikels, SF Taylor… - Dialogues in clinical …, 2001 - Taylor & Francis
There are substantial declines in behavioral measures of cognitive function with age,
including decreased function of executive processes and long-term memory. There is also …