Pyroptosis was long regarded as caspase-1-mediated monocyte death in response to
certain bacterial insults. Caspase-1 is activated upon various infectious and immunological …

Pyroptosis is an inflammatory form of cell death that not only protects multicellular organisms
from invading pathogenic bacteria and microbial infections, but can also lead to sepsis and …

Inflammatory caspases drive a lytic form of cell death called pyroptosis in response to
microbial infection and endogenous damage-associated signals. Two studies now …

Pyroptosis is a lytic type of programmed cell death that was traditionally associated with the
involvement of inflammatory caspases, such as caspase-1. These inflammatory caspases …

Pyroptosis is a programmed necrotic cell death executed by gasdermins, a family of pore-
forming proteins. The cleavage of gasdermins by specific proteases enables their pore …

Pyroptosis is a lytic type of cell death that is initiated by inflammatory caspases. These
caspases are activated within multi‐protein inflammasome complexes that assemble in …

Pyroptosis is a necrotic form of cell death that was initially found to be induced upon
activation of inflammatory caspases by inflammasome complexes. Mechanistically …

Pyroptosis is a form of lytic programmed cell death initiated by inflammasomes, which detect
cytosolic contamination or perturbation. This drives activation of caspase-1 or caspase …

Pyroptosis is a proinflammatory form of cell death, mediated by membrane pore-forming
proteins called gasdermins. Gasdermin pores allow the release of the pro-inflammatory …

Pyroptosis is the process of inflammatory cell death. The primary function of pyroptosis is to
induce strong inflammatory responses that defend the host against microbe infection …