Significant advances have been made in bone tissue engineering (TE) in the past decade. However, classical bone TE strategies have been hampered mainly due to the lack of …
Y Liu, JKY Chan, SH Teoh - Journal of tissue engineering and …, 2015 - Wiley Online Library
Poor angiogenesis within tissue‐engineered grafts has been identified as a main challenge limiting the clinical introduction of bone tissue‐engineering (BTE) approaches for the repair …
A Stahl, YP Yang - Tissue Engineering Part B: Reviews, 2021 - liebertpub.com
A variety of engineered materials have gained acceptance in orthopedic practice as substitutes for autologous bone grafts, although the regenerative efficacy of these …
The development of tissue engineering strategies for treatment of large bone defects has become increasingly relevant, given the growing demand for bone substitutes. Native bone …
Y Liu, J Lim, SH Teoh - Biotechnology advances, 2013 - Elsevier
Clinical translation of scaffold-based bone tissue engineering (BTE) therapy still faces many challenges despite intense investigations and advancement over the years. To address …
U Kneser, DJ Schaefer… - Journal of cellular …, 2006 - Wiley Online Library
Bone defects represent a medical and socioeconomic challenge. Different types of biomaterials are applied for reconstructive indications and receive rising interest. However …
MI Santos, RL Reis - Macromolecular bioscience, 2010 - Wiley Online Library
The lack of a functional vascular supply has, to a large extent, hampered the whole range of clinical applications of 'successful'laboratory‐based bone tissue engineering strategies. To …
JR García, AJ García - Drug delivery and translational research, 2016 - Springer
Repair of non-healing bone defects through tissue engineering strategies remains a challenging feat in the clinic due to the aversive microenvironment surrounding the injured …
F Simunovic, G Finkenzeller - Cells, 2021 - mdpi.com
Bone is a highly vascularized tissue, and its development, maturation, remodeling, and regeneration are dependent on a tight regulation of blood vessel supply. This condition also …