Reduced levels of brain derived neurotrophic factor (BDNF) in the serum of diabetic retinopathy patients and in the retina of diabetic rats

MS Ola, MI Nawaz, AA El-Asrar, M Abouammoh… - Cellular and molecular …, 2013 - Springer
Diabetic retinopathy (DR) is widely recognized as a neurovascular disease. Retina, being a
neuronal tissue of the eye, produces neurotrophic factors for its maintenance. However …

Relationship between stages of diabetic retinopathy and levels of brain-derived neurotrophic factor in aqueous humor and serum

AGT Uzel, N UĞurlu, Y Toklu, M Cicek, B Boral… - Retina, 2020 - journals.lww.com
Purpose: The aim of the study was to determine aqueous humor and serum levels of brain-
derived neurotrophic factor (BDNF) in diabetic patients with and without retinopathy …

Involvement of brain-derived neurotrophic factor in early retinal neuropathy of streptozotocin-induced diabetes in rats: therapeutic potential of brain-derived …

M Seki, T Tanaka, H Nawa, T Usui, T Fukuchi… - Diabetes, 2004 - Am Diabetes Assoc
Although neurotrophins have been assessed as candidate therapeutic agents for neural
complications of diabetes, their involvement in diabetic retinopathy has not been fully …

Neurotrophins and neurotrophin receptors in proliferative diabetic retinopathy

AM Abu El-Asrar, G Mohammad, G De Hertogh… - PLoS …, 2013 - journals.plos.org
Neurotrophins (NTs) are emerging as important mediators of angiogenesis and fibrosis. We
investigated the expression of the NTs nerve growth factor (NGF), brain-derived …

BDNF protects retinal neurons from hyperglycemia through the TrkB/ERK/MAPK pathway

Y Liu, L Tao, X Fu, Y Zhao, X Xu - Molecular medicine …, 2013 - spandidos-publications.com
Diabetic retinopathy (DR) is one of the most common diabetic eye diseases and a leading
cause of blindness. It is characterized by changes in the blood vessels of the retina. The …

Decreased serum brain-derived neurotrophic factor in Chinese patients with type 2 diabetes mellitus

M He, J Wang - Acta Biochim Biophys Sin, 2014 - academic.oup.com
Brain-derived neurotrophic factor (BDNF) is a member of neurotrophin family associated
with the proliferation, differentiation, activity-dependent plasticity, and survival of neurons in …

BDNF is upregulated by postnatal development and visual experience: quantitative and immunohistochemical analyses of BDNF in the rat retina

M Seki, H Nawa, T Fukuchi, H Abe… - … ophthalmology & visual …, 2003 - iovs.arvojournals.org
purpose. This study sought to elucidate changes in the levels and distribution of brain-
derived neurotrophic factor (BDNF) in the retina throughout aging and depending on visual …

Diabetic retinopathy and BDNF: a review on its molecular basis and clinical applications

M Afarid, E Namvar… - Journal of ophthalmology, 2020 - Wiley Online Library
Impairment of neuroprotection and vasculopathy are the main reasons for the progression of
diabetic retinopathy. In this review, we decided to illustrate the molecular and clinical …

[HTML][HTML] Neuroprotective and restorative effects of the brain-derived neurotrophic factor in retinal diseases

M Afarid, M Torabi-Nami, B Zare - Journal of the Neurological Sciences, 2016 - Elsevier
Brain-derived neurotrophic factor (BDNF) is a neurotrophin proposed to be implicated in
ameliorating the course of some neurodegenerative disorders. Given the fact that retina is …

Relationship between levels of brain‐derived neurotrophic factor and metabolic parameters in patients with type 2 diabetes mellitus

B Boyuk, S Degirmencioglu, H Atalay… - Journal of diabetes …, 2014 - Wiley Online Library
Background and Aim. Studies have suggested that brain‐derived neurotrophic factor
(BDNF) plays a role in glucose and lipid metabolism and inflammation. The aim of this study …