The ability to modify existing microbiota at different sites presents enormous potential for
local or indirect management of various diseases. Because bacteria can be maintained for …

The controlled in situ delivery of biologics (eg enzymes, cytokines, antibodies) by
engineered bacteria of our microbiome will allow the sustainable production of these …

Synthetic biology can be defined as the design and construction of novel biologically based
parts, devices and systems, as well as the redesign of existing natural biological systems, for …

A complex interplay of metabolic and immunological mechanisms underlies many diseases
that represent a substantial unmet medical need. There is an increasing appreciation of the …

The emergence of synthetic biology is holding great hopes for providing solutions to the
unmet needs of humankind. This review article describes how synthetic biology can deliver …

Highlights•Engineered bacteria provide a continuous supply of therapeutic
molecules.•Bacterial therapies target inflammation, immunity, cancer, and metabolic …

The rising prevalence of antibiotic resistant microbial pathogens presents an ominous health
and economic challenge to modern society. The discovery and large-scale development of …

Highlights•Synthetic biology is quickly moving from proof of concept to industrial
application.•Pharmaceuticals are a promising target for advanced genetic …

The human microbiome plays an important role in human health, from metabolism to
immunity. In the last few decades, advances in synthetic biology have enabled scientists to …

Synthetic biology is a relatively new field with the key aim of designing and constructing
biological systems with novel functionalities. Today, synthetic biology devices are making …