The development of the human kidney is a complex process that requires interactions
between epithelial and mesenchymal cells, eventually leading to the coordinated growth …

The mammalian kidney consists of highly specialised cells that function in an integrated
manner to maintain homeostasis of body fluids, electrolytes and nutrients. Formation of …

Development of an organ is directed by cell and tissue interactions and these also occur
during the formation of functional kidney. During vertebrate development inductive signalling …

Background: Kidney diseases are worldwide public health problems with a high cost and
increasing incidence. By revealing the genetic and cellular mechanism behind mammalian …

The mammalian permanent kidney consists of three cell lineages of different origin: the
epithelial cells of the ureter bud, the mesenchymal cells of the nephric blastema and the …

In recent years, a great deal has been learnt about the molecular regulation of kidney
development. While most research has focused on the molecular regulation of ureteric …

The mammalian metanephric kidney is composed of two epithelial components, the
collecting duct system and the nephron epithelium, that differentiate from two different …

Over the recent decades there has been extensive investigation into the genetic/molecular
regulation and cellular/molecular mechanisms of nephrogenesis and ultimate kidney …

Mammalian nephrogenesis depends on the interaction between the ureteric bud and the
metanephric mesenchyme. As the ureteric bud undergoes branching and segmentation, the …

Although it is not easy to investigate the regulatory basis of developmental processes in
most mammalian tissues, the mouse kidney has several distinct advantages as a model …