The E11. 5 mouse metanephros is comprised of a T-stage ureteric epithelial tubule sub-
divided into tip and trunk cells surrounded by metanephric mesenchyme (MM). Tip cells are …

Conversion of renal mesenchyme into epithelia depends on the ureteric bud, but its specific
actions are not established. From conditioned media of ureteric bud cells, we have identified …

The uriniferous tubule is divided into the proximal tubule, the intermediate (thin) tubule, the
distal tubule and the collecting duct. The present chapter is based on the chapters by …

Kidney Development, Disease, Repair and Regeneration focuses on the molecular and
cellular basis of kidney development, exploring the origins of kidney lineages, the …

The nephron is a multifunctional filtration device equipped with an array of sophisticated
sensors. For appropriate physiological function in the human and mouse, nephrons must be …

A kidney is an organ with relatively low basal cellular regenerative potential. However, renal
cells have a pronounced ability to proliferate after injury, which undermines that the kidney …

Many of the functions of the kidney are carried out by two cell types, the epithelial and the
endothelial cells. Epithelial cells constitute the distal and proximal tubuli, and the visceral …

The adult kidney is highly vascular and receives about 20% of the cardiac output, yet the
mode of development of the glomerular capillaries is not fully understood. At the inception of …

The rat urinary system, consisting of the kidney, ureters, urinary bladder, and urethra, is
highly immature at birth. The kidney is morphologically mature by PND 30. Not all parts of …

The molecular regulation of the complex inductive events associated with formation of the
vertebrate excretory system has been progressively elucidated as a result of both genetic …