Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), which are pivotal sensors of
RNA virus invasions, mediate the transcriptional induction of genes encoding type I …

The innate immune system senses RNA virus infections through membrane-bound Toll-like
receptors or the cytoplasmic proteins RIG-I and MDA-5. RIG-I is believed to recognize the …

RIG-I is a critical RNA virus sensor that serves to initiate antiviral innate immunity. However,
posttranslational regulation of RIG-I signaling remains to be fully understood. We report here …

The cellular response to virus infection is initiated when pathogen recognition receptors
(PRR) engage viral pathogen-associated molecular patterns (PAMPs). This process results …

The innate RNA sensor RIG-I is critical in the initiation of antiviral type I interferons (IFNs)
production upon recognition of" non-self" viral RNAs. Here, we identify a host-derived, IFN …

Establishing the balance between positive and negative innate immune mechanisms is
crucial for maintaining homeostasis. Here we uncover the regulatory crosstalk between two …

Highlights•RIG-I and MDA5 oligomerize the respective 2CARDs upon viral RNA
recognition.•There are ubiquitin-dependent and ubiquitin-independent mechanisms to …

Background RIG-I is a pivotal receptor that detects numerous RNA and DNA viruses. Thus,
its defectiveness may strongly impair the host antiviral immunity. Remarkably, very little …

The RIG-I-like receptors (RLRs) signal innate immune defenses upon RNA virus infection,
but their roles in adaptive immunity have not been clearly defined. Here, we showed that the …

Recognition of invading viruses by the host is elicited by cellular sensors which trigger
signaling cascades that lead to type I interferon (IFN) gene expression. Retinoic acid …