Inflammatory bowel disease (IBD), a general term encompassing Crohn's disease (CD) and
ulcerative colitis (UC), and other conditions, is a chronic and relapsing autoimmune disease …

Abstract Cholesterol 25-hydroxylase (CH25H) encodes the enzyme that converts cholesterol
to 25-hydroxycholesterol (25-HC). 25-HC has been demonstrated to be involved in the …

Background & Aims Cholesterol 25-hydroxylase (Ch25h), converting cholesterol to 25-
hydroxycholesterol (25-HC), is critical in modulating cellular lipid metabolism and anti …

Intestinal fibrosis and stenosis are common complications of Crohn's disease [CD],
frequently requiring surgery. Anti-inflammatory strategies can only partially prevent fibrosis; …

Background High-fat diet (HFD) is closely associated with the increased prevalence of
inflammatory bowel disease (IBD). Excessive gut microbial metabolite deoxycholic acid …

Obesity is a major risk factor for several diseases including diabetes, heart disease, and
some forms of cancer and due to its rapidly increasing prevalence it has become one of the …

Cholesterol is an essential molecule for life. It is a component of the cell membrane, and it is
a precursor molecule for bile acids, vitamin D and steroid hormones. Cholesterol is actively …

Background: Cross-talk between sterol metabolism and inflammatory pathways has been
demonstrated to significantly affect the development of atherosclerosis. Cholesterol …

Objective Expansion of visceral adipose tissue (VAT) and metabolic inflammation are
consequences of obesity and associated with type 2 diabetes (T2DM). Metabolically …

Cholesterol and components of the cholesterol biosynthetic pathway have fundamental
roles in all mammalian cells. Hydroxylated forms of cholesterol are now emerging as …