Inflammatory bowel disease (IBD) is characterized by chronic, uncontrolled inflammation in
the intestinal mucosa. Although the etiology is poorly understood, it is widely accepted that …

Interferons (IFNs) play a central role in immunity and emerging evidence suggests that IFN-
signalling coordinately regulates sterol biosynthesis in macrophages, via Sterol Regulatory …

Sterol 12α-hydroxylase (CYP8B1) catalyzes cholic acid synthesis in the liver and is
feedback inhibited by bile acids. In addition to activating farnesoid X receptor (nuclear …

Aims: Cluster of differentiation 36 (CD36) is involved in the development of nonalcoholic
steatohepatitis (NASH). Excess CD36 facilitates liver cells taking fatty acid and activates …

Background Inflammatory states such as hepatitis and sepsis are frequently associated with
alterations of bile acid synthesis. These conditions are mediated by bacterial wall products …

Background & Aims Chronic inflammation surrounding bile ducts contributes to the disease
pathogenesis of most cholangiopathies. Poor efficacy of immunosuppression in these …

Immunoglobulin A (IgA) secretion by plasma cells, terminally differentiated B cells residing in
the intestinal lamina propria, assures microbiome homeostasis and protects the host against …

Abstract Background and Aim Epigenetic modification is an important part of the
pathogenesis of inflammatory bowel disease (IBD). Some studies proved that p62 was …

The behaviors of lymphocytes, including CD4+ T helper cells, are controlled on many levels
by internal metabolic properties. Lipid metabolites have recently been ascribed a novel …

Inflammatory bowel disease is a chronic, idiopathic and complex condition, which most often
manifests itself in the form of ulcerative colitis or Crohn's disease. Both forms are associated …