Background. Infection with any of the 4 related dengue virus serotypes (DENV-1–4) is
thought to result in lifelong immunity to homotypic reinfection (ie, reinfection with the same …

To the Editor: Dengue is one of the most widespread infectious diseases globally;
transmission now occurs in 128 countries. Although dengue virus (DENV) control strategies …

The immune response to dengue virus (DENV) infection is complex and not fully
understood. Using longitudinal data from 181 children with dengue in Thailand who were …

Dengue viruses (DENVs) are mosquito-borne flaviviruses that infect humans. The clinical
presentation of DENV infection ranges from inapparent infection to dengue hemorrhagic …

Background. Antibodies induced by infection with any 1 of 4 dengue virus (DENV) serotypes
(DENV-1–4) may influence the clinical outcome of subsequent heterologous infections. To …

Immunity to a single dengue virus (DENV) infection does not provide heterologous immunity
to subsequent infection. In fact, the greatest risk for dengue hemorrhagic fever (DHF) is with …

The prevailing global spread of four dengue virus (DENV) serotypes and the resultant co-
circulation of multiple serotypes in the same region have invariably led to conditions …

Although heterotypic secondary infection with dengue virus (DENV) is associated with
severe disease, the majority of secondary infections are mild or asymptomatic. The …

Severity of disease is markedly increased when infection with dengue virus type 2 (DENV-2)
follows infection with DENV-1. Studies have shown that heterologous neutralizing antibody …

To investigate the incidence of dengue virus (DENV) infection in Nicaragua, a 2‐year
prospective study was conducted in schoolchildren 4–16 years old in the capital city of …