Currently, most in vitro engineered bone tissues do not contain viable blood vessel systems,
so the vascularization depends on post-implantation angiogenesis from the host, which is …

Objectives The bone tissue engineering primarily focuses on three‐dimensional co‐culture
systems, which physical and biological properties resemble the cell matrix of actual tissues …

Bone represents a highly dynamic tissue whose development is strongly dependent on
vasculogenic and angiogenic processes. Neovascularization also plays an important role in …

Tissue‐engineered bone provides a promising method for the rehabilitation of acquired
bone defects and congenital deformities. However, generating a vascular supply to the …

Over-dependence on existing synthetic scaffolds and insufficient vascularization limit the
development of tissue engineered bone (TEB). The purpose of this study is to fabricate …

To introduce a functional vascular network into tissue‐engineered bone equivalents, human
endothelial colony forming cells (ECFCs) and multipotent mesenchymal stromal cells …

The development of technologies to promote vascularization of engineered tissue would
drive major developments in tissue engineering and regenerative medicine. Recently, we …

The neovascularization of three‐dimensional voluminous tissues, such as bone, represents
an important challenge in tissue engineering applications. The formation of a preformed …

Human mesenchymal stem cells (hMSCs) can be derived from various adult and fetal
tissues. However, the quality of tissues for the isolation of adult and fetal hMSCs is donor …

Vascularization of engineered bone tissue is critical for ensuring its survival after
implantation. In vitro pre-vascularization of bone grafts with endothelial cells is a promising …