Mnd1 is required for meiotic interhomolog repair
Background: While double-strand break (DSB) repair is vital to the survival of cells during
both meiosis and mitosis, the preferred mechanism of repair differs drastically between the …
both meiosis and mitosis, the preferred mechanism of repair differs drastically between the …
MND1 enables homologous recombination in somatic cells primarily outside the context of replication
Faithful and timely repair of DNA double‐strand breaks (DSBs) is fundamental for the
maintenance of genomic integrity. Here, we demonstrate that the meiotic recombination co …
maintenance of genomic integrity. Here, we demonstrate that the meiotic recombination co …
Repair of meiotic DNA breaks and homolog pairing in mouse meiosis requires a minichromosome maintenance (MCM) paralog
The mammalian Mcm-domain containing 2 (Mcmdc2) gene encodes a protein of unknown
function that is homologous to the minichromosome maintenance family of DNA replication …
function that is homologous to the minichromosome maintenance family of DNA replication …
The Mnd1 protein forms a complex with hop2 to promote homologous chromosome pairing and meiotic double-strand break repair
H Tsubouchi, GS Roeder - Molecular and cellular biology, 2002 - Taylor & Francis
The hop2 mutant of Saccharomyces cerevisiae arrests in meiosis with extensive
synaptonemal complex (SC) formation between nonhomologous chromosomes. A screen …
synaptonemal complex (SC) formation between nonhomologous chromosomes. A screen …
High copy number suppression of the meiotic arrest caused by a dmc1 mutation: REC114 imposes an early recombination block and RAD54 promotes a DMC1 …
Background DMC1, the meiosis‐specific eukaryotic homologue of bacterial recA, is required
for completion of meiotic recombination and cell cycle progression past prophase. In a dmc1 …
for completion of meiotic recombination and cell cycle progression past prophase. In a dmc1 …
Chromosome synapsis alleviates Mek1-dependent suppression of meiotic DNA repair
VV Subramanian, AJ MacQueen, G Vader… - PLoS …, 2016 - journals.plos.org
Faithful meiotic chromosome segregation and fertility require meiotic recombination
between homologous chromosomes rather than the equally available sister chromatid, a …
between homologous chromosomes rather than the equally available sister chromatid, a …
Mek1 suppression of meiotic double-strand break repair is specific to sister chromatids, chromosome autonomous and independent of Rec8 cohesin complexes
TL Callender, NM Hollingsworth - Genetics, 2010 - academic.oup.com
During meiosis, recombination is directed to occur between homologous chromosomes to
create connections necessary for proper segregation at meiosis I. Partner choice is …
create connections necessary for proper segregation at meiosis I. Partner choice is …
Mnd1p: an evolutionarily conserved protein required for meiotic recombination
JL Gerton, JL DeRisi - … of the National Academy of Sciences, 2002 - National Acad Sciences
We used a functional genomics approach to identify a gene required for meiotic
recombination, YGL183c or MND1. MND1 was spliced in meiotic cells, extending the …
recombination, YGL183c or MND1. MND1 was spliced in meiotic cells, extending the …
Atmnd1-Δ1 is sensitive to gamma-irradiation and defective in meiotic DNA repair
S Domenichini, C Raynaud, DA Ni, Y Henry… - DNA repair, 2006 - Elsevier
The efficient repair of double-strand breaks (DSBs) in genomic DNA is crucial for the survival
of all organisms. Mnd1 is suggested to promote the strand invasion step during meiotic …
of all organisms. Mnd1 is suggested to promote the strand invasion step during meiotic …
Evidence that MEK1 positively promotes interhomologue double-strand break repair
Y Terentyev, R Johnson, MJ Neale… - Nucleic acids …, 2010 - academic.oup.com
During meiosis there is an imperative to create sufficient crossovers for homologue
segregation. This can be achieved during repair of programmed DNA double-strand breaks …
segregation. This can be achieved during repair of programmed DNA double-strand breaks …