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Glucose metabolism is of critical importance for cell growth and proliferation, the disorders of
which have been widely implicated in cancer progression. Glucose uptake is achieved …

Oncogenic PIK3CA mutations are found in a significant fraction of human cancers, but
therapeutic inhibition of PI3K has only shown limited success in clinical trials. To understand …

Reprogramming of cell metabolism is essential for tumorigenesis, and is regulated by a
complex network, in which PKM2 plays a critical role. PKM2 exists as an inactive monomer …

Maintenance of stem/progenitor cell-progeny relationships is required for tissue
homeostasis during normal turnover and repair. Wnt signaling is implicated in both …

Cancer is driven by incremental changes that accumulate, eventually leading to oncogenic
transformation. Although genetic alterations dominate the way cancer biologists think about …

Aberrations in the phosphoinositide 3-kinase (PI3K) signaling pathway play a key role in the
pathogenesis of numerous cancers by altering cellular growth, metabolism, proliferation …

Following 3 decades of extensive research into PI3K signaling, it is now evidently clear that
the underlying network does not equate to a simple ON/OFF switch. This is best illustrated by …

The PI3K/AKT pathway is a key target in oncology where most efforts are focussed on
phenotypes such as cell proliferation and survival. Comparatively, little attention has been …

The connection between cell fate transitions and metabolic shifts is gaining momentum in
the study of cell differentiation in embryonic development, adult stem cells, and cancer …