Self-reported symptoms of COVID-19, including symptoms most predictive of SARS-CoV-2 infection, are heritable

FMK Williams, MB Freidin, M Mangino… - Twin research and …, 2020 - cambridge.org
Susceptibility to infection such as SARS-CoV-2 may be influenced by host genotype.
TwinsUK volunteers (n= 3261) completing the C-19 COVID-19 symptom tracker app allowed …

Human genetic factors associated with susceptibility to SARS-CoV-2 infection and COVID-19 disease severity

C Anastassopoulou, Z Gkizarioti, GP Patrinos… - Human genomics, 2020 - Springer
Background The emergence of the novel coronavirus in Wuhan, Hubei Province, China, in
December 2019 marked the synchronization of the world to a peculiar clock that is counting …

[HTML][HTML] A global effort to define the human genetics of protective immunity to SARS-CoV-2 infection

JL Casanova, HC Su, L Abel, A Aiuti, S Almuhsen… - Cell, 2020 - cell.com
SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from
silent infection to lethal disease. The role of human genetics in determining clinical response …

Novel genes and sex differences in COVID-19 severity

R Cruz, S Diz-de Almeida… - Human Molecular …, 2022 - academic.oup.com
Here, we describe the results of a genome-wide study conducted in 11 939 coronavirus
disease 2019 (COVID-19) positive cases with an extensive clinical information that were …

Host genetic factors determining COVID-19 susceptibility and severity

TP Velavan, SR Pallerla, J Rüter, Y Augustin… - …, 2021 - thelancet.com
The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus-2
(SARS-CoV-2) poses an unprecedented challenge to humanity. SARS-CoV-2 infections …

A phenome‐wide investigation of risk factors for severe COVID‐19

A Baranova, H Cao, S Teng… - Journal of Medical …, 2023 - Wiley Online Library
With the continued spread of COVID‐19 globally, it is crucial to identify the potential risk or
protective factors associated with COVID‐19. Here, we performed genetic correlation …

Trans-ancestry analysis reveals genetic and nongenetic associations with COVID-19 susceptibility and severity

JF Shelton, AJ Shastri, C Ye, CH Weldon… - Nature Genetics, 2021 - nature.com
COVID-19 presents with a wide range of severity, from asymptomatic in some individuals to
fatal in others. Based on a study of 1,051,032 23andMe research participants, we report …

The human genetic epidemiology of COVID-19

MEK Niemi, MJ Daly, A Ganna - Nature Reviews Genetics, 2022 - nature.com
Human genetics can inform the biology and epidemiology of coronavirus disease 2019
(COVID-19) by pinpointing causal mechanisms that explain why some individuals become …

Trans-ethnic analysis reveals genetic and non-genetic associations with COVID-19 susceptibility and severity

JF Shelton, AJ Shastri, C Ye, CH Weldon… - MedRxiv, 2020 - medrxiv.org
COVID-19 presents with a wide range of severity, from asymptomatic in some individuals to
fatal in others. Based on a study of over one million 23andMe research participants, we …

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

M D'Antonio, JP Nguyen, TD Arthur, H Matsui… - Cell reports, 2021 - cell.com
Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between
individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive …