Highlights•SARS-CoV-2 infection in vitro triggers activation of the NLRP3
inflammasome.•The NLRP3 is activated in mice infected with SARS-CoV-2 and in the lungs …

NLRP3 inflammasome is a critical immune component that plays a crucial role in mounting
innate immune responses. The deleterious effects of inflammasome activation have been …

Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), exhibits a wide spectrum of clinical presentations …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the genus
Betacoronavirus within the family Coronaviridae. It is an enveloped single-stranded positive …

Severe cases of COVID-19 are characterized by a strong inflammatory process that may
ultimately lead to organ failure and patient death. The NLRP3 inflammasome is a molecular …

Abstract SARS‐CoV‐2 triggers inflammasome‐dependent release of pro‐inflammatory
cytokine IL‐1β and pyroptosis, therefore, contributes to the huge inflammatory response …

A hyperinflammatory response during severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection crucially worsens clinical evolution of coronavirus disease 2019 …

The coronavirus disease 2019 (COVID-19) global pandemic, caused by severe acute
respiratory syndrome coronavirus type 2 (SARS-CoV-2), has been marked by severe cases …

Despite the initial success of some drugs and vaccines targeting COVID-19, understanding
the mechanism underlying SARS-CoV-2 disease pathogenesis remains crucial for the …

Severe cases of COVID-19 are characterized by a strong inflammatory process that may
ultimately lead to organ failure and patient death. The NLRP3 inflammasome is a molecular …