Molecular analysis of cerebrospinal fluid in viral diseases of the central nervous system

P Cinque, S Bossolasco, Å Lundkvist - Journal of Clinical Virology, 2003 - Elsevier
The use of nucleic acid (NA) amplification techniques has transformed the diagnosis of viral
infections of the central nervous system (CNS). Because of their enhanced sensitivity, these …

Molecular methods for diagnosis of viral encephalitis

RL DeBiasi, KL Tyler - Clinical microbiology reviews, 2004 - Am Soc Microbiol
Hundreds of viruses cause central nervous system (CNS) disease, including
meningoencephalitis and postinfectious encephalomyelitis, in humans. The cerebrospinal …

Clinical implications of nucleic acid amplification methods for the diagnosis of viral infections of the nervous system

T Weber, S Frye, M Bodemer, M Otto… - Journal of …, 1996 - Taylor & Francis
Amplification of viral nucleic acids from the cerebrospinal fluid (CSF) has considerably
improved the diagnosis of several acute, subacute and chronic viral infections of the nervous …

Molecular detection of viral causes of encephalitis and meningitis in New York State

M Dupuis, R Hull, H Wang, S Nattanmai… - Journal of medical …, 2011 - Wiley Online Library
The etiology of encephalitis and meningitis, serious diseases of the central nervous system
(CNS), in most cases remains unknown. The importance of establishing a diagnosis …

[PDF][PDF] Molecular analysis of cerebrospinal fluid: potential for the study of HIV-1 infection of the central nervous system

P Cinque, A Bestetti, P Morelli, S Presi - Journal of neurovirology, 2000 - jneurovirol.com
The molecular analysis of cerebrospinal uid (CSF) provides an inestimable tool for the study
of HIV infection of the central nervous system (CNS). Current nucleic acid ampli® cation …

Clinical application of viral cerebrospinal fluid PCR testing for diagnosis of central nervous system disorders: a retrospective 11-year experience

M Kleines, S Scheithauer, J Schiefer… - … microbiology and infectious …, 2014 - Elsevier
The cerebrospinal fluid (CSF) polymerase chain reaction (PCR) is the gold standard to
detect cerebral viral activity. As positive findings do not prove an impact on the neurological …

Application of PCR for various neurotropic viruses on the diagnosis of viral meningitis

M Hosoya, K Honzumi, M Sato, M Katayose… - Journal of clinical …, 1998 - Elsevier
Background: Epidemiological studies have indicated that the majority of cases of aseptic
meningitis result from viral infections. However, specific viral pathogens for aseptic …

Virological diagnosis of central nervous system infections by use of PCR coupled with mass spectrometry analysis of cerebrospinal fluid samples

N Lévêque, J Legoff, C Mengelle… - Journal of Clinical …, 2014 - Am Soc Microbiol
Viruses are the leading cause of central nervous system (CNS) infections, ahead of bacteria,
parasites, and fungal agents. A rapid and comprehensive virologic diagnostic testing …

Polymerase chain reaction on cerebrospinal fluid for diagnosis of virus-associated opportunistic diseases of the central nervous system in HIV-infected patients

P Cinque, L Vago, H Dahl, M Brytting, MR Terreni… - Aids, 1996 - journals.lww.com
Objective: To assess the diagnostic reliability of polymerase chain reaction (PCR) on
cerebrospinal fluid (CSF) for virus-associated opportunistic diseases of the central nervous …

Diagnosis of viral infections of the central nervous system: clinical interpretation of PCR results

KJM Jeffery, SJ Read, TEA Peto, RT Mayon-White… - The Lancet, 1997 - thelancet.com
Background Standard laboratory techniques, such as viral culture and serology, provide
only circumstantial or retrospective evidence of viral infections of the central nervous system …