The genetics of bipolar disorder

FJA Gordovez, FJ McMahon - Molecular psychiatry, 2020 - nature.com
Bipolar disorder (BD) is one of the most heritable mental illnesses, but the elucidation of its
genetic basis has proven to be a very challenging endeavor. Genome-Wide Association …

Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder

L Hou, SE Bergen, N Akula, J Song… - Human molecular …, 2016 - academic.oup.com
Bipolar disorder (BD) is a genetically complex mental illness characterized by severe
oscillations of mood and behaviour. Genome-wide association studies (GWAS) have …

[PDF][PDF] A cytogenetic abnormality and rare coding variants identify ABCA13 as a candidate gene in schizophrenia, bipolar disorder, and depression

HM Knight, BS Pickard, A Maclean, MP Malloy… - The American Journal of …, 2009 - cell.com
Schizophrenia and bipolar disorder are leading causes of morbidity across all populations,
with heritability estimates of∼ 80% indicating a substantial genetic component. Population …

[PDF][PDF] Genomic dissection of bipolar disorder and schizophrenia, including 28 subphenotypes

DM Ruderfer, S Ripke, A McQuillin, J Boocock… - Cell, 2018 - cell.com
Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology.
Understanding the genetic factors contributing to the shared and disorder-specific symptoms …

Genome-wide association study of bipolar disorder in Canadian and UK populations corroborates disease loci including SYNE1 and CSMD1

W Xu, S Cohen-Woods, Q Chen, A Noor, J Knight… - BMC medical …, 2014 - Springer
Background Recently, genome-wide association studies (GWAS) for cases versus controls
using single nucleotide polymorphism microarray data have shown promising findings for …

A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11. 2

SD Detera-Wadleigh, JA Badner… - Proceedings of the …, 1999 - National Acad Sciences
Bipolar disorder is a severe mental illness characterized by mood swings of elation and
depression. Family, twin, and adoption studies suggest a complex genetic etiology that may …

Whole-genome association study of bipolar disorder

P Sklar, JW Smoller, J Fan, MAR Ferreira… - Molecular …, 2008 - nature.com
We performed a genome-wide association scan in 1461 patients with bipolar (BP) 1
disorder, 2008 controls drawn from the Systematic Treatment Enhancement Program for …

Genome-wide survey implicates the influence of copy number variants (CNVs) in the development of early-onset bipolar disorder

L Priebe, FA Degenhardt, S Herms, B Haenisch… - Molecular …, 2012 - nature.com
We used genome-wide single nucleotide polymorphism (SNP) data to search for the
presence of copy number variants (CNVs) in 882 patients with bipolar disorder (BD) and 872 …

Translational genomics and beyond in bipolar disorder

C Zhang, X Xiao, T Li, M Li - Molecular psychiatry, 2021 - nature.com
Genome-wide association studies (GWAS) have revealed multiple genomic loci conferring
risk of bipolar disorder (BD), providing hints for its underlying pathobiology. However, there …

Exome sequencing for bipolar disorder points to roles of de novo loss-of-function and protein-altering mutations

M Kataoka, N Matoba, T Sawada, AA Kazuno… - Molecular …, 2016 - nature.com
Although numerous genetic studies have been conducted for bipolar disorder (BD), its
genetic architecture remains elusive. Here we perform, to the best of our knowledge, the first …